{"id":"W2626313504","doi":"10.1093/biolre/iox060","title":"Inhibition of polyamine synthesis causes entry of the mouse blastocyst into embryonic diapause†","year":2017,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Biology; Blastocyst; Diapause; Conceptus; Embryonic stem cell; Trophoblast; Embryo; Ornithine decarboxylase; Cell biology; Arginase; Andrology; Embryogenesis; Endocrinology; Internal medicine; Fetus; Placenta; Genetics; Pregnancy; Enzyme; Biochemistry; Arginine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003279752,0.0005137731,0.0004742305,0.0004962511,0.0002044176,0.00038898,0.000523917,0.0006299426,0.002103169],"category_scores_gemma":[0.0002256933,0.0003606088,0.0004100599,0.0002176158,0.0003647355,0.0002428406,0.000367146,0.001562039,0.0007418904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003932463,"about_ca_system_score_gemma":0.0003506969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001285007,"about_ca_topic_score_gemma":0.002354707,"domain_scores_codex":[0.9995573,0.00005835905,0.00007675368,0.00009198029,0.0001121973,0.0001032974],"domain_scores_gemma":[0.9995297,0.0001314353,0.0001003815,0.00005519458,0.00002580076,0.0001574972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001787819,0.0000429167,0.0002334299,0.00004460099,0.000007700164,0.0000836547,0.00002781294,0.00002810603,0.9983212,0.0000955405,0.00005513515,0.0008810681],"study_design_scores_gemma":[0.00002592314,0.0007068337,0.005506089,0.00001681419,0.0000159749,0.0001975196,0.00003227873,0.0004678546,0.9902789,0.00004139086,0.002704922,0.000005383392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825426,0.005581507,0.003078281,0.0004142691,0.0001339109,0.0001889154,0.001975725,0.0002836895,0.005801127],"genre_scores_gemma":[0.9777154,0.002447073,0.002757215,0.0004286859,0.0000360589,0.0002147808,0.001927085,0.0001154254,0.01435825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002103169,"threshold_uncertainty_score":0.007035851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01095069748121896,"score_gpt":0.2582077100652667,"score_spread":0.2472570125840478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}