{"id":"W2626758605","doi":"10.1016/j.bbapap.2017.06.009","title":"The unfolding mechanism of monomeric mutant SOD1 by simulated force spectroscopy","year":2017,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Force Microscopy Techniques and Applications","field":"Physics and Astronomy","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Compute Canada","keywords":"Force spectroscopy; Intramolecular force; Chemistry; Monomer; Dissociation (chemistry); Crystallography; Energy landscape; Protein folding; Sequence (biology); Biophysics; Chemical physics; Stereochemistry; Molecule; Physical chemistry; Biochemistry; Biology; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001911411,0.0003122033,0.0001899946,0.0001829993,0.000326906,0.0002099249,0.0003931727,0.0004817918,0.0007948573],"category_scores_gemma":[0.0003463831,0.0001828524,0.0002650364,0.0001458115,0.000292403,0.0003539098,0.0001748975,0.0006287639,0.00009141542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005594768,"about_ca_system_score_gemma":0.0002840258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002061028,"about_ca_topic_score_gemma":0.001014999,"domain_scores_codex":[0.9999341,0.000009011359,0.000003293728,0.0000197085,0.00002211807,0.00001163518],"domain_scores_gemma":[0.9999198,0.00002779434,0.00001210909,0.00001053072,0.00001807331,0.00001164933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002644461,0.00008461368,0.002062767,0.00006505691,0.00003063721,0.0001357877,0.0002250337,0.02240307,0.9685302,0.00183232,0.0002721062,0.004093959],"study_design_scores_gemma":[0.00003697965,0.0002071367,0.007944914,0.00001118911,0.00001565996,0.0001249236,0.00008881625,0.5746201,0.4148204,0.001211404,0.0008765807,0.00004198853],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961124,0.00008239943,0.003172857,0.00008161796,0.000008344888,0.00000931277,0.00006709518,0.00005548939,0.000410469],"genre_scores_gemma":[0.9982986,0.00005759317,0.001333646,0.00001029386,0.000002070999,0.000007292692,0.00005905467,0.000005968993,0.0002255352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002061028,"threshold_uncertainty_score":0.004097998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007357390989039161,"score_gpt":0.2640398926403269,"score_spread":0.2566825016512878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}