{"id":"W2626981951","doi":"10.1016/s1474-4422(17)30122-9","title":"Prediction of cognition in Parkinson's disease with a clinical–genetic score: a longitudinal analysis of nine cohorts","year":2017,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":189,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"National Institute on Aging; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Sanofi-Aventis Korea Company; Parkinsonfonden; Genentech; Ipsen; Medical Research Council; Physicians' Services Incorporated Foundation; Servier; Rosetrees Trust; H. Lundbeck A/S; Assistance Publique - Hôpitaux de Paris; Prinses Beatrix Spierfonds; University of Toronto; ZonMw; Biogen; Agence Nationale de la Recherche; Ipsen Fund; National Institutes of Health; Voyager Therapeutics; National Institute for Health and Care Research; Fondation Brain Canada; Novartis; Parkinson Study Group; W. Garfield Weston Foundation; Edmond J. Safra Philanthropic Foundation; GlaxoSmithKline; University of Ottawa; Wellcome Trust; Advanced Cardiac Therapeutics; Bristol-Myers Squibb; Cephalon; Teva Pharmaceutical Industries; National Parkinson Foundation; Pfizer; University of Rochester; Parkinson's UK; Brigham and Women's Hospital; Harvard NeuroDiscovery Center; National Institute of Neurological Disorders and Stroke; Stichting ParkinsonFonds; Ontario Brain Institute; Lundbeckfonden; U.S. Department of Defense; Eli Lilly and Company; American Parkinson Disease Association; UCB; Parkinson's Disease Foundation; Parkinson Vereniging; Parkinson Society Canada; Michael J. Fox Foundation for Parkinson's Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Cognition; Parkinson's disease; Medicine; Disease; Longitudinal study; Internal medicine; Physical medicine and rehabilitation; Psychology; Psychiatry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003287422,0.0009319746,0.0007706621,0.0009060329,0.001466442,0.001648591,0.001034873,0.001328183,0.0009170155],"category_scores_gemma":[0.004325199,0.0007195749,0.001774328,0.001705459,0.0008653364,0.001180415,0.001749702,0.001769777,0.0002341682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007883816,"about_ca_system_score_gemma":0.0007585482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02263071,"about_ca_topic_score_gemma":0.01933223,"domain_scores_codex":[0.9982436,0.0006444409,0.0001539806,0.0005902597,0.0001764751,0.0001913038],"domain_scores_gemma":[0.9967812,0.0005646804,0.0009866143,0.0005869978,0.0005887077,0.0004917951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007229861,0.00007873698,0.9965655,0.000006667638,0.0008403579,0.0001398405,0.0001798084,0.00009759804,0.0003401553,0.00004064346,0.0001371866,0.0008504194],"study_design_scores_gemma":[0.00004313908,0.000178186,0.99857,0.000006386084,0.0002333883,0.0001768522,0.0001841209,0.0003032238,0.00006039086,0.00007907968,0.0001531167,0.00001221043],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990907,0.0001926701,0.0001318472,0.00005899566,0.00001524263,0.000005954249,0.0003799064,0.000004053852,0.0001205982],"genre_scores_gemma":[0.9987765,0.0001001846,0.0001604238,0.00003056965,0.0000117089,0.00001049354,0.0007355681,0.000005368459,0.0001693298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02263071,"threshold_uncertainty_score":0.04499799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07448044597737412,"score_gpt":0.325283804314126,"score_spread":0.2508033583367519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}