{"id":"W2626981951","doi":"10.1016/s1474-4422(17)30122-9","title":"Prediction of cognition in Parkinson's disease with a clinical–genetic score: a longitudinal analysis of nine cohorts","year":2017,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":189,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"National Institute on Aging; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Sanofi-Aventis Korea Company; Parkinsonfonden; Genentech; Ipsen; Medical Research Council; Physicians' Services Incorporated Foundation; Servier; Rosetrees Trust; H. Lundbeck A/S; Assistance Publique - Hôpitaux de Paris; Prinses Beatrix Spierfonds; University of Toronto; ZonMw; Biogen; Agence Nationale de la Recherche; Ipsen Fund; National Institutes of Health; Voyager Therapeutics; National Institute for Health and Care Research; Fondation Brain Canada; Novartis; Parkinson Study Group; W. Garfield Weston Foundation; Edmond J. Safra Philanthropic Foundation; GlaxoSmithKline; University of Ottawa; Wellcome Trust; Advanced Cardiac Therapeutics; Bristol-Myers Squibb; Cephalon; Teva Pharmaceutical Industries; National Parkinson Foundation; Pfizer; University of Rochester; Parkinson's UK; Brigham and Women's Hospital; Harvard NeuroDiscovery Center; National Institute of Neurological Disorders and Stroke; Stichting ParkinsonFonds; Ontario Brain Institute; Lundbeckfonden; U.S. Department of Defense; Eli Lilly and Company; American Parkinson Disease Association; UCB; Parkinson's Disease Foundation; Parkinson Vereniging; Parkinson Society Canada; Michael J. Fox Foundation for Parkinson's Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Cognition; Parkinson's disease; Medicine; Disease; Longitudinal study; Internal medicine; Physical medicine and rehabilitation; Psychology; Psychiatry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002388828,0.0001083838,0.0006584619,0.0001395906,0.00005638602,0.00000558916,0.0001338801,0.00005250333,0.00005000335],"category_scores_gemma":[0.0001227705,0.00006882044,0.0001216669,0.0001630807,0.0002696172,0.00003269629,0.00004415996,0.0001309059,0.000001957963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005901638,"about_ca_system_score_gemma":0.00005619579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008370366,"about_ca_topic_score_gemma":0.0001814807,"domain_scores_codex":[0.9989348,0.0001364975,0.0003006606,0.000279021,0.0001741468,0.0001748395],"domain_scores_gemma":[0.9986691,0.00008273557,0.0003664758,0.0007181498,0.00006666297,0.00009688636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005961121,0.0004601846,0.9909025,0.00003525472,0.0008544336,0.0003298873,0.00001394011,0.00007631927,0.00006449057,0.00003991492,0.00003704095,0.001224935],"study_design_scores_gemma":[0.003395603,0.0009884994,0.9883414,0.0000421823,0.004527065,0.00001406407,0.000001539866,0.002110051,0.00006115605,0.0002293249,0.0002484212,0.00004068719],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977489,0.0001832489,0.0001149609,0.001156426,0.00007204499,0.0003330663,0.0001568402,0.00001316166,0.000221325],"genre_scores_gemma":[0.9991089,0.0003623469,0.00006519061,0.0002520784,0.00008822903,0.00004362376,0.00005491111,0.00000990177,0.00001486802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003672631,"threshold_uncertainty_score":0.2806416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07448044597737412,"score_gpt":0.325283804314126,"score_spread":0.2508033583367519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}