{"id":"W2627058122","doi":"10.1038/s41598-017-04256-w","title":"The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington’s disease","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; CHDI Foundation","keywords":"Neuroprotection; Huntington's disease; FOXO3; Biology; Transcription factor; Huntingtin; Activator (genetics); Neuroscience; Cell biology; Genetics; Disease; Medicine; Receptor; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004928084,0.0002479775,0.0002062814,0.0001677063,0.0001713404,0.0001867112,0.00009548882,0.0001330767,0.001912181],"category_scores_gemma":[0.00005418303,0.000109153,0.0002648763,0.00009382424,0.0001619437,0.0001621233,0.0001788568,0.0002340242,0.0003806529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002734885,"about_ca_system_score_gemma":0.0002213892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009877308,"about_ca_topic_score_gemma":0.002038308,"domain_scores_codex":[0.9999473,0.000002634939,0.000005599294,0.00001640731,0.000016201,0.0000118133],"domain_scores_gemma":[0.9999254,0.000004043191,0.0000328127,0.000006194,0.000009758732,0.00002178231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000876881,0.000007026963,0.0005504392,0.00002708494,0.000004128256,0.00006063988,0.000005753531,0.00002848703,0.9978738,0.00004472903,0.00003495144,0.001275306],"study_design_scores_gemma":[0.00002190702,0.0002368575,0.0831632,0.00002249589,0.00003701497,0.0008607199,0.00005832982,0.0006817188,0.9075207,0.0001948818,0.007192778,0.000009424862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943987,0.001507894,0.001412459,0.00008874315,0.00001850241,0.00001415206,0.001008078,0.00009326786,0.00145827],"genre_scores_gemma":[0.9932076,0.001022079,0.001782037,0.00004508725,0.000005702604,0.0000186194,0.001238368,0.00002698972,0.002653588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001912181,"threshold_uncertainty_score":0.00639689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01846412594046959,"score_gpt":0.2549307302988808,"score_spread":0.2364666043584112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}