{"id":"W2627062370","doi":"10.1172/jci89934","title":"Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; McMaster University; University of Minnesota","keywords":"Carbohydrate-responsive element-binding protein; Fructose; Transcription factor; Biology; Endocrinology; Chemistry; Internal medicine; Cell biology; Biochemistry; Medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001345665,0.000256023,0.000286425,0.0001669688,0.0001368548,0.0002074107,0.0001686857,0.0001958005,0.00233959],"category_scores_gemma":[0.0001420184,0.00008499807,0.0002240247,0.0001053857,0.0001820655,0.0001941669,0.0002754779,0.0005764122,0.0003590641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001840504,"about_ca_system_score_gemma":0.0001730537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000403425,"about_ca_topic_score_gemma":0.0005575064,"domain_scores_codex":[0.999915,0.00001391767,0.000005980837,0.00001752753,0.00001625951,0.00003132327],"domain_scores_gemma":[0.9999341,0.000005607994,0.00001920094,0.000008522943,0.00001139938,0.00002118515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005206574,0.00005200913,0.0003464494,0.0000865265,0.000009492293,0.00005068549,0.00001118276,0.00008845078,0.9959692,0.0001378024,0.0001213014,0.00260632],"study_design_scores_gemma":[0.00008766315,0.0007234049,0.02144595,0.00002516096,0.00003493756,0.0003487792,0.00007528528,0.001417102,0.9685981,0.0001665432,0.007063763,0.00001324483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872828,0.003595882,0.006241958,0.0003140349,0.00008099894,0.00004618091,0.0004430778,0.0002357753,0.001759364],"genre_scores_gemma":[0.9940712,0.001581381,0.001647122,0.00009466893,0.00002058892,0.00003494879,0.0005027987,0.00002063295,0.002026661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00233959,"threshold_uncertainty_score":0.007826746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1728546053160219,"score_gpt":0.4165621666235441,"score_spread":0.2437075613075222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}