{"id":"W2627871710","doi":"10.1001/jama.2017.7112","title":"Risks of Breast, Ovarian, and Contralateral Breast Cancer for <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers","year":2017,"lang":"en","type":"article","venue":"JAMA","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2863,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Sinai Health System; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Cancer Institute; Pomorski Uniwersytet Medyczny W Szczecinie; Universität zu Köln; Centre Hospitalier Universitaire de Québec; Gentofte Hospital; Karolinska Institutet; Universität Wien; Medizinische Universität Wien; Peter MacCallum Cancer Centre; University of New South Wales; National Breast Cancer Foundation; Universitätsklinikum Köln; National Institute for Health and Care Research; Cancer Research UK; Deutschen Konsortium für Translationale Krebsforschung; QIMR Berghofer Medical Research Institute; Lunds Universitet; Deutsches Krebsforschungszentrum; Université Laval","keywords":"Medicine; Breast cancer; Oncology; Ovarian cancer; Mutation; Gynecology; Internal medicine; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008664865,0.0002272742,0.0002290271,0.0007409736,0.0002088986,0.0003719405,0.0002471162,0.0002673405,0.00151258],"category_scores_gemma":[0.002445408,0.0001737193,0.0004499294,0.0006647675,0.0001851546,0.0002903496,0.0003201664,0.0002743987,0.0001312122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002231645,"about_ca_system_score_gemma":0.0002835634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006524375,"about_ca_topic_score_gemma":0.008822531,"domain_scores_codex":[0.999607,0.00009298239,0.00003514677,0.0001355706,0.00007433309,0.00005488206],"domain_scores_gemma":[0.9986664,0.0002474461,0.0007587167,0.0001129787,0.00008880297,0.0001256863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009625355,0.000006271673,0.9979137,0.000005471382,0.00005368543,0.00002607327,0.000015254,0.00003631745,0.00008154853,0.00002011756,0.00008685142,0.001658483],"study_design_scores_gemma":[0.00001283135,0.00005520982,0.9987127,0.00001036887,0.00007601188,0.0003825622,0.00007117587,0.0002154195,0.0001038001,0.00007198047,0.000284908,0.000003072847],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978063,0.0006938967,0.0001542268,0.00006926552,0.000006832508,0.000006759537,0.0008070265,0.00000604888,0.0004497228],"genre_scores_gemma":[0.998584,0.0002675215,0.0001913791,0.0000250685,0.00001105377,0.000007849355,0.0006455032,0.000002607107,0.0002650395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006524375,"threshold_uncertainty_score":0.01297283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01911752846076883,"score_gpt":0.3105289127953287,"score_spread":0.2914113843345598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}