{"id":"W2629949851","doi":"10.1016/j.clinthera.2017.05.014","title":"The Pharmacodynamic Effects of Rituximab at Very Low Doses","year":2017,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Apotex (Canada)","funders":"","keywords":"Medicine; Rituximab; Pharmacokinetics; Biosimilar; Pharmacodynamics; Dosing; Pharmacology; Randomized controlled trial; Internal medicine; Immunogenicity; Gastroenterology; Immunology; Antibody; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005734119,0.0002356008,0.0003711637,0.0001823033,0.00014029,0.000733533,0.0003057285,0.0006755241,0.00230411],"category_scores_gemma":[0.001820483,0.0001639536,0.0004017641,0.0001247972,0.0004141724,0.0004670448,0.0001649518,0.001318564,0.0006485207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003499265,"about_ca_system_score_gemma":0.0002982185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003381746,"about_ca_topic_score_gemma":0.0002650329,"domain_scores_codex":[0.9993547,0.0003074262,0.00002749751,0.00006659688,0.0001426498,0.0001012443],"domain_scores_gemma":[0.9991399,0.0005055254,0.0001193703,0.00009209757,0.00005746075,0.0000856393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03659774,0.0009284099,0.003938529,0.0002146597,0.0002898374,0.0005709587,0.0001463218,0.002097986,0.8824114,0.0009530286,0.002515395,0.06933571],"study_design_scores_gemma":[0.001341384,0.03129965,0.03553638,0.00004482539,0.0005538928,0.003470114,0.000144372,0.009202074,0.9051976,0.001037782,0.01209765,0.00007425882],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857174,0.005995721,0.0033647,0.0006964085,0.000185951,0.00003632772,0.000279695,0.0001242255,0.00359965],"genre_scores_gemma":[0.9979408,0.0004451288,0.0004234141,0.0002025626,0.00006243143,0.00001207053,0.000159364,0.0000176075,0.00073655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00230411,"threshold_uncertainty_score":0.007708013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06536303396905699,"score_gpt":0.4256538472883188,"score_spread":0.3602908133192618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}