{"id":"W264127248","doi":"10.1023/a:1022976528441","title":"Phase I and Pharmacologic Study of the Human DNA Methyltransferase Antisense Oligodeoxynucleotide MG98 given as a 21-day Continuous Infusion Every 4 Weeks","year":2003,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pyrogenesis (Canada); BC Cancer Agency; Ontario Institute for Cancer Research","funders":"","keywords":"Pharmacokinetics; Pharmacology; Toxicity; Medicine; DNMT1; Hemoglobin; Chemistry; Methyltransferase; Internal medicine; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006521667,0.001772536,0.002158019,0.0006839937,0.0005746607,0.0009306325,0.00138742,0.001842919,0.002175807],"category_scores_gemma":[0.0005875537,0.0008488044,0.0009785271,0.0005151051,0.001248458,0.0007252134,0.0002229997,0.002985452,0.0006598964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000942828,"about_ca_system_score_gemma":0.002302634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001699357,"about_ca_topic_score_gemma":0.003296822,"domain_scores_codex":[0.9996093,0.0001309121,0.00001314392,0.0000769227,0.00004001578,0.0001297543],"domain_scores_gemma":[0.9995171,0.00008435821,0.0001047923,0.00006011534,0.00003527624,0.0001985035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6192992,0.1118987,0.003028776,0.0004443997,0.0007322829,0.0003543013,0.0002758073,0.004467477,0.1720553,0.001276644,0.00469985,0.08146723],"study_design_scores_gemma":[0.2683624,0.6984095,0.003582454,0.00002612131,0.0003146454,0.0002582054,0.00007770913,0.001239314,0.02288548,0.0003650308,0.004440029,0.00003914625],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910255,0.001387782,0.001156111,0.0004454753,0.0002183334,0.002422871,0.0009352496,0.000135303,0.002273311],"genre_scores_gemma":[0.9833808,0.001802259,0.002427538,0.0006971334,0.0002542064,0.004104647,0.001498939,0.00005775337,0.005776748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002175807,"threshold_uncertainty_score":0.0072788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01797658233807913,"score_gpt":0.306791163502084,"score_spread":0.2888145811640048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}