{"id":"W264127248","doi":"10.1023/a:1022976528441","title":"Phase I and Pharmacologic Study of the Human DNA Methyltransferase Antisense Oligodeoxynucleotide MG98 given as a 21-day Continuous Infusion Every 4 Weeks","year":2003,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pyrogenesis (Canada); BC Cancer Agency; Ontario Institute for Cancer Research","funders":"","keywords":"Pharmacokinetics; Pharmacology; Toxicity; Medicine; DNMT1; Hemoglobin; Chemistry; Methyltransferase; Internal medicine; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004389444,0.0001569061,0.0001757413,0.00005385904,0.0002127567,0.00002743806,0.0001774418,0.00007818931,0.00005021132],"category_scores_gemma":[0.0003096485,0.0001218934,0.00006883648,0.0001452131,0.000224835,0.00001045871,0.00007941565,0.0001370703,0.000003166035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001264544,"about_ca_system_score_gemma":0.0002425012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002324926,"about_ca_topic_score_gemma":0.00004322136,"domain_scores_codex":[0.9984943,0.0003888191,0.0002760244,0.0003104334,0.0003122266,0.000218147],"domain_scores_gemma":[0.9993069,0.000065873,0.00009093116,0.0002228927,0.0001039961,0.0002094386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000424361,0.0003671004,0.005617303,0.000009856242,0.00008090595,0.00000944663,0.0004179122,0.00003923417,0.9905332,0.0003176196,0.001955083,0.0006098575],"study_design_scores_gemma":[0.005738851,0.001270329,0.007394942,0.00002812143,0.00006393769,0.00002373817,0.0005614714,0.00005797658,0.9799559,0.001474831,0.003227561,0.0002023968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981965,0.0001842424,0.00002757177,0.0004728613,0.00006275406,0.000518484,0.00001950005,0.000008917714,0.0005091592],"genre_scores_gemma":[0.9975345,0.00004312407,0.0001384467,0.0006204993,0.00007553698,0.00001613574,0.00002682686,0.00001563616,0.001529323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0105774,"threshold_uncertainty_score":0.497067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01797658233807913,"score_gpt":0.306791163502084,"score_spread":0.2888145811640048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}