{"id":"W2644016119","doi":"10.1021/acs.jpcb.7b04671","title":"A Pseudohypervalent Sulfur Intermediate as an Oxidative Protective Mechanism in the Archaea Peroxiredoxin Enzyme ApTPx","year":2017,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Archaea; Peroxiredoxin; Mechanism (biology); Oxidative phosphorylation; Enzyme; Sulfur; Chemistry; Oxidative damage; Biochemistry; Peroxidase; Physics; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002195429,0.000373946,0.000512264,0.0001746949,0.0005996736,0.0006805018,0.0006243507,0.000659078,0.001141699],"category_scores_gemma":[0.0002543387,0.0003324397,0.0005829886,0.0001485832,0.0005039726,0.0006817654,0.0005512775,0.000383933,0.00008554629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004826004,"about_ca_system_score_gemma":0.0006990993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003137026,"about_ca_topic_score_gemma":0.002308822,"domain_scores_codex":[0.9999385,0.00001207503,0.000003045313,0.00001289199,0.00001640951,0.00001702936],"domain_scores_gemma":[0.9999502,0.00001413978,0.000009549833,0.000006007434,0.000007117994,0.00001300768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008593214,0.0003901148,0.0251286,0.0004103057,0.0002515123,0.001656322,0.0003786342,0.7970907,0.1429014,0.02291101,0.0005604142,0.007461659],"study_design_scores_gemma":[0.0001187121,0.0002547117,0.003927803,0.00001306932,0.00005703964,0.0001082052,0.0001946986,0.9804823,0.01003891,0.004195407,0.0005804721,0.00002863419],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941122,0.0001270387,0.004380077,0.0001175333,0.00001193191,0.00001245113,0.00005140915,0.00004149628,0.001145867],"genre_scores_gemma":[0.9970382,0.0001286739,0.00241253,0.00002282721,0.000003310361,0.00001546649,0.00006449952,0.000007571142,0.0003068751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003137026,"threshold_uncertainty_score":0.006237507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142595780374167,"score_gpt":0.2905367220132414,"score_spread":0.2762771439758247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}