{"id":"W2646893109","doi":"10.1016/j.str.2017.05.020","title":"Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly","year":2017,"lang":"en","type":"article","venue":"Structure","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; AbbVie; Merck; Pfizer; Fundação de Amparo à Pesquisa do Estado de São Paulo; Boehringer Ingelheim; Janssen Biotech; Innovative Medicines Initiative; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Waters Corporation","keywords":"Dodecameric protein; Biophysics; Chemistry; Active site; Biochemistry; Protein structure; Structural biology; Catalysis; Biology; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007748695,0.0003108973,0.0001656315,0.0001993579,0.0002036146,0.0002438024,0.0002211031,0.0003199266,0.001822779],"category_scores_gemma":[0.0001589619,0.0001248992,0.0002061048,0.0001973112,0.000176561,0.0005046192,0.0002025166,0.0006340055,0.00018338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002835663,"about_ca_system_score_gemma":0.0001600355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008353629,"about_ca_topic_score_gemma":0.001079841,"domain_scores_codex":[0.9999695,0.000003533961,0.000001897724,0.000008412282,0.000009182358,0.000007471742],"domain_scores_gemma":[0.9999417,0.00001599194,0.00001408817,0.000005675366,0.000006243886,0.00001633714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003951266,0.0001260396,0.005273015,0.000247125,0.00005533024,0.000952907,0.0002541759,0.006473523,0.960369,0.004291469,0.001197233,0.02036523],"study_design_scores_gemma":[0.0001196182,0.0004672669,0.04838365,0.00005913517,0.0001429443,0.002729165,0.0005295494,0.1060483,0.8050172,0.006341837,0.03007841,0.00008282218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832759,0.001573718,0.01153969,0.0002442312,0.0000230811,0.00001099562,0.0004373608,0.0001807712,0.002714303],"genre_scores_gemma":[0.9926797,0.0004053597,0.005814184,0.00003707329,0.000004748929,0.000005257758,0.0005583533,0.00001206906,0.0004832555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001822779,"threshold_uncertainty_score":0.006097794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007947900555440682,"score_gpt":0.2581036547202991,"score_spread":0.2501557541648584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}