{"id":"W2647027503","doi":"10.15252/embj.201696386","title":"Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA‐guided gene silencing in vivo","year":2017,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Bayerisches Staatsministerium für Bildung und Kultus, Wissenschaft und Kunst; Canadian HIV Trials Network, Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Biology; Argonaute; Gene silencing; Cell biology; Phosphorylation; RNA-induced silencing complex; RNA; RNA-binding protein; Messenger RNA; RNA silencing; Gene expression; RNA interference; Gene; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006644692,0.00007611576,0.0001079973,0.0000469086,0.0003729282,0.00009062479,0.0002204924,0.00005042633,0.000008373398],"category_scores_gemma":[0.0001534425,0.00005575317,0.00005983412,0.00002304147,0.00006747701,0.00001086418,0.00008773914,0.0001146993,3.994805e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001356274,"about_ca_system_score_gemma":0.00007022894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000410038,"about_ca_topic_score_gemma":0.00002785766,"domain_scores_codex":[0.9993688,0.00003842492,0.0001543932,0.0001195685,0.0001116207,0.0002072126],"domain_scores_gemma":[0.9994602,0.00001513703,0.0002091948,0.0001982772,0.00006164734,0.00005553376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001127603,0.00001157938,0.001432415,0.00001915928,0.0000290288,0.00000350418,0.0001246505,0.00002274247,0.9965057,0.00001079212,0.0004686528,0.001258971],"study_design_scores_gemma":[0.0008213778,0.0001320398,0.003460723,0.00005911391,0.000009129925,0.00007198299,0.00006193914,0.0007349251,0.9942952,0.0001258424,0.0001617668,0.00006596921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973803,0.0004297403,0.001413519,0.0003423388,0.00008364402,0.0002452131,0.000009075746,0.000001133377,0.0000950417],"genre_scores_gemma":[0.9982313,0.0003198947,0.0007570544,0.00002886499,0.0002396713,0.00000784525,0.000001889555,0.00001068141,0.0004027847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002210555,"threshold_uncertainty_score":0.28683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01771797101858371,"score_gpt":0.2976678134421962,"score_spread":0.2799498424236125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}