{"id":"W2647027503","doi":"10.15252/embj.201696386","title":"Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA‐guided gene silencing in vivo","year":2017,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Bayerisches Staatsministerium für Bildung und Kultus, Wissenschaft und Kunst; Canadian HIV Trials Network, Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Biology; Argonaute; Gene silencing; Cell biology; Phosphorylation; RNA-induced silencing complex; RNA; RNA-binding protein; Messenger RNA; RNA silencing; Gene expression; RNA interference; Gene; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002867548,0.0006760068,0.0003795426,0.0002235093,0.0004233921,0.0005937407,0.0005380507,0.0006166673,0.002855259],"category_scores_gemma":[0.0003339731,0.0006102968,0.0004993855,0.000129938,0.0006746378,0.0004342959,0.0005187312,0.0008897002,0.0009170548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004827064,"about_ca_system_score_gemma":0.0002512888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005664763,"about_ca_topic_score_gemma":0.001088182,"domain_scores_codex":[0.9996172,0.00007764013,0.00003837846,0.0001089107,0.00007645553,0.00008135421],"domain_scores_gemma":[0.9996715,0.00007486806,0.0001125596,0.00004763245,0.00001266143,0.00008077985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004847201,0.00003077396,0.0001578449,0.00002460356,0.00001271134,0.00008127344,0.00000792822,0.0001002609,0.9981012,0.0002991881,0.00006696901,0.0006325807],"study_design_scores_gemma":[0.0000394344,0.00009085983,0.003314515,0.000003809781,0.00001538175,0.0002768893,0.00001107487,0.001554764,0.9936649,0.0001993587,0.0008183228,0.00001073379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940976,0.001021418,0.002507827,0.0002690865,0.0001134906,0.00001508406,0.0002424287,0.0001231632,0.001609907],"genre_scores_gemma":[0.9974335,0.0001971335,0.0008741813,0.0000862234,0.00001150072,0.00001061924,0.0002017253,0.00007616638,0.001108911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002855259,"threshold_uncertainty_score":0.009551823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01771797101858371,"score_gpt":0.2976678134421962,"score_spread":0.2799498424236125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}