{"id":"W2651436262","doi":"10.1002/wdev.281","title":"Signaling and epigenetic mechanisms of intestinal stem cells and progenitors: insight into crypt homeostasis, plasticity, and niches","year":2017,"lang":"en","type":"review","venue":"Wiley Interdisciplinary Reviews Developmental Biology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Stem cell; Biology; Cell biology; Progenitor cell; Wnt signaling pathway; Adult stem cell; Cellular differentiation; Epigenetics; Regeneration (biology); Notch signaling pathway; Crypt; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003502177,0.0003368389,0.000371905,0.0006937413,0.0003633312,0.0009233578,0.0003711522,0.0006535377,0.00240346],"category_scores_gemma":[0.0002317821,0.0002249524,0.0002733271,0.0005504435,0.0008745194,0.001047211,0.0006968483,0.001045193,0.000783827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00077109,"about_ca_system_score_gemma":0.0005542823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006769181,"about_ca_topic_score_gemma":0.001175136,"domain_scores_codex":[0.9998407,0.00002030939,0.000007783428,0.00003965729,0.0000573992,0.00003406282],"domain_scores_gemma":[0.9998972,0.00002265091,0.00001882718,0.000009732266,0.00002432337,0.00002724681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002124399,0.00004773773,0.002429406,0.002258178,0.00005493615,0.0009655817,0.0005922228,0.001792811,0.5742214,0.0557544,0.00774478,0.3539261],"study_design_scores_gemma":[0.00002990055,0.0002793164,0.01658352,0.0006723687,0.0001530065,0.002993345,0.0007732536,0.005190241,0.3166426,0.03510836,0.6214753,0.00009877334],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09235477,0.8251897,0.03971134,0.008731812,0.001075525,0.00006170259,0.0007401301,0.0005639459,0.03157116],"genre_scores_gemma":[0.3977285,0.556788,0.01319432,0.001885465,0.0007741596,0.0001067799,0.0007432782,0.0001503614,0.02862904],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00240346,"threshold_uncertainty_score":0.008040428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09348381372828538,"score_gpt":0.3671662298027223,"score_spread":0.2736824160744369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}