{"id":"W2652345243","doi":"10.1200/po.16.00031","title":"Homologous Recombination Deficiency in Breast Cancer: A Clinical Review","year":2017,"lang":"en","type":"review","venue":"JCO Precision Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Homologous recombination; Breast cancer; Homologous chromosome; BRCA2 Protein; Medicine; DNA repair; Germline mutation; Germline; Cancer; Clinical significance; Bioinformatics; Mutation; Genetics; Biology; Internal medicine; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007349577,0.0007596944,0.001348394,0.002842902,0.0002954257,0.001010774,0.001058985,0.0009776349,0.004258922],"category_scores_gemma":[0.001326344,0.0002998604,0.0006449921,0.002815385,0.0003877664,0.00114622,0.0006904527,0.001517989,0.001957584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005284771,"about_ca_system_score_gemma":0.001196644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00111007,"about_ca_topic_score_gemma":0.002452391,"domain_scores_codex":[0.9997684,0.00004131429,0.00004580469,0.0000371349,0.0000907903,0.00001657102],"domain_scores_gemma":[0.9993556,0.000352877,0.00008897194,0.00001401198,0.000148695,0.00003986421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005524432,0.00005096072,0.0001793364,0.02845794,0.0001005883,0.0001640246,0.0000545201,0.0002536297,0.0004386501,0.002078968,0.0403266,0.9278395],"study_design_scores_gemma":[0.00001992324,0.00008964838,0.0007717153,0.01631206,0.0001983929,0.00157717,0.00006646998,0.00007437459,0.0001828206,0.001659026,0.9790268,0.00002155523],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004178423,0.9990773,0.00004316317,0.0002021396,0.0001163397,0.000004483081,0.00001434548,0.000003579757,0.000496782],"genre_scores_gemma":[0.0002402298,0.9993091,0.00008118809,0.0001221039,0.00008171467,0.000003845647,0.00001796098,7.64356e-7,0.0001431662],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004258922,"threshold_uncertainty_score":0.01424754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3056827032087479,"score_gpt":0.5919253871315462,"score_spread":0.2862426839227983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}