{"id":"W2652345243","doi":"10.1200/po.16.00031","title":"Homologous Recombination Deficiency in Breast Cancer: A Clinical Review","year":2017,"lang":"en","type":"review","venue":"JCO Precision Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Homologous recombination; Breast cancer; Homologous chromosome; BRCA2 Protein; Medicine; DNA repair; Germline mutation; Germline; Cancer; Clinical significance; Bioinformatics; Mutation; Genetics; Biology; Internal medicine; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004041131,0.0005188152,0.005325775,0.000512918,0.0001234579,0.00002260577,0.0006711388,0.001458161,0.001840487],"category_scores_gemma":[0.0009779878,0.0004033223,0.0009994033,0.0004573159,0.0002968306,0.000115737,0.0001978846,0.001752271,0.0006087633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002226204,"about_ca_system_score_gemma":0.00401585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007384967,"about_ca_topic_score_gemma":0.0000744347,"domain_scores_codex":[0.9936493,0.001552156,0.002761974,0.001089756,0.0004520153,0.0004948056],"domain_scores_gemma":[0.99452,0.001319061,0.00215489,0.001431777,0.0003289655,0.0002452756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009452931,0.0005976906,0.00011438,0.01308424,0.00005141371,0.0002170395,0.00001010475,6.988979e-8,8.471608e-8,0.00003755321,0.0495903,0.9362026],"study_design_scores_gemma":[0.001819461,0.0005814736,0.0005181264,0.1300766,0.0006945495,0.002229203,0.000001512,0.000002381895,8.951339e-8,0.0002090263,0.8635736,0.0002940251],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00000659242,0.9775131,0.00001964224,0.00426339,0.003145135,0.003136603,0.0001152901,0.00007367908,0.01172655],"genre_scores_gemma":[0.000005525233,0.9936821,0.0003472513,0.001916889,0.0006350143,0.001501507,0.0001491718,0.00007643783,0.001686145],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9359086,"threshold_uncertainty_score":0.9998419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3056827032087479,"score_gpt":0.5919253871315462,"score_spread":0.2862426839227983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}