{"id":"W2653632515","doi":"10.1016/s1470-2045(17)30381-9","title":"Doxorubicin plus evofosfamide versus doxorubicin alone in locally advanced, unresectable or metastatic soft-tissue sarcoma (TH CR-406/SARC021): an international, multicentre, open-label, randomised phase 3 trial","year":2017,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":306,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Doxorubicin; Medicine; Open label; Soft tissue sarcoma; Sarcoma; Oncology; Phases of clinical research; Internal medicine; Chemotherapy; Soft tissue; Clinical trial; Radiology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001296998,0.001639483,0.002428299,0.0004404376,0.0002916571,0.0009649359,0.0008127468,0.001453849,0.007928702],"category_scores_gemma":[0.001160713,0.0005140905,0.001635408,0.0003768731,0.001047992,0.001203879,0.0004524032,0.003220381,0.001368543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008681654,"about_ca_system_score_gemma":0.0007736141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026627,"about_ca_topic_score_gemma":0.002829303,"domain_scores_codex":[0.9995806,0.0002203696,0.00001840582,0.00008950308,0.00002177739,0.00006944351],"domain_scores_gemma":[0.9993948,0.0001774877,0.0001188576,0.00003846797,0.00002406405,0.000246306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9679709,0.003510537,0.0003442648,0.0006827469,0.0006979692,0.0000345348,0.00006012032,0.0006754703,0.00292935,0.0001939601,0.001202702,0.02169744],"study_design_scores_gemma":[0.9279788,0.06885027,0.001124881,0.00005057346,0.0002888276,0.00003900471,0.00002707524,0.0004677446,0.0003029807,0.0002168354,0.0006371116,0.00001580421],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865427,0.005291779,0.0006534471,0.001003599,0.0006582909,0.001461137,0.001017819,0.0001550114,0.003216297],"genre_scores_gemma":[0.9844139,0.003785997,0.001299673,0.001198376,0.0003472995,0.001764152,0.001470656,0.00004615007,0.005673893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007928702,"threshold_uncertainty_score":0.02652413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1883823477514966,"score_gpt":0.4786800370415504,"score_spread":0.2902976892900538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}