{"id":"W2653859450","doi":"10.1016/j.jid.2017.05.033","title":"Hidradenitis Suppurativa Is Characterized by Dysregulation of the Th17:Treg Cell Axis, Which Is Corrected by Anti-TNF Therapy","year":2017,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Hidradenitis Suppurativa and Treatments","field":"Medicine","cited_by":218,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"British Skin Foundation","keywords":"Hidradenitis suppurativa; Immune dysregulation; Medicine; Proinflammatory cytokine; Pathogenesis; Immunology; Tumor necrosis factor alpha; Immune system; Cytokine; Regulatory T cell; T cell; Interleukin 17; Inflammation; Disease; Pathology; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004001002,0.0004041261,0.0004786012,0.0004205209,0.0002687812,0.0003588317,0.0001722035,0.0002965166,0.001417008],"category_scores_gemma":[0.0003098876,0.0001245456,0.0003879157,0.0002149264,0.0003600396,0.0002200648,0.0003303539,0.0008003127,0.0003221397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001836565,"about_ca_system_score_gemma":0.0002328744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002090656,"about_ca_topic_score_gemma":0.0003496892,"domain_scores_codex":[0.999674,0.0000945367,0.00003836224,0.00004192361,0.00006255726,0.00008870634],"domain_scores_gemma":[0.9997434,0.00003713117,0.0001140363,0.00002104484,0.00003110819,0.00005326038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002551009,0.0006583341,0.02767266,0.001855978,0.0002225396,0.0102245,0.0002256293,0.0002265655,0.8237038,0.001307811,0.003694746,0.1276564],"study_design_scores_gemma":[0.001389136,0.008194959,0.3383133,0.0007753531,0.0007227747,0.09165566,0.001520055,0.002008131,0.3921095,0.002810766,0.1603977,0.0001026794],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.879365,0.1029544,0.004934747,0.00142797,0.001131104,0.0001846131,0.0005551148,0.0003229106,0.009124122],"genre_scores_gemma":[0.9810123,0.0134506,0.001894689,0.0004922207,0.0005016427,0.00007097017,0.0003003128,0.00001836617,0.002258847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001417008,"threshold_uncertainty_score":0.004740357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02129982562793909,"score_gpt":0.2726101338208635,"score_spread":0.2513103081929244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}