{"id":"W2653859450","doi":"10.1016/j.jid.2017.05.033","title":"Hidradenitis Suppurativa Is Characterized by Dysregulation of the Th17:Treg Cell Axis, Which Is Corrected by Anti-TNF Therapy","year":2017,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Hidradenitis Suppurativa and Treatments","field":"Medicine","cited_by":218,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"British Skin Foundation","keywords":"Hidradenitis suppurativa; Immune dysregulation; Medicine; Proinflammatory cytokine; Pathogenesis; Immunology; Tumor necrosis factor alpha; Immune system; Cytokine; Regulatory T cell; T cell; Interleukin 17; Inflammation; Disease; Pathology; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001966644,0.0003441269,0.001030823,0.0001338805,0.0003995817,0.0000692776,0.0004544689,0.0002752056,0.0003964245],"category_scores_gemma":[0.0002613396,0.0002211539,0.0002559052,0.000214507,0.0009484297,0.0005856508,0.00006531264,0.000511528,0.00001996813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007589511,"about_ca_system_score_gemma":0.0003827101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005085475,"about_ca_topic_score_gemma":0.000006010636,"domain_scores_codex":[0.997565,0.0004205788,0.0009258174,0.0002531825,0.0005106162,0.0003248223],"domain_scores_gemma":[0.99577,0.0001596001,0.002399849,0.0005331652,0.0008962887,0.0002410801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003025941,0.000519191,0.1188562,0.00007767291,0.0005964488,0.001569491,0.004469522,2.531858e-8,0.8084311,0.00003854972,0.06371202,0.001427111],"study_design_scores_gemma":[0.005245603,0.0003823565,0.06527855,0.0002066398,0.0001610337,0.03144868,0.000248469,0.00004057871,0.8909912,0.0003412156,0.005480007,0.000175731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9051017,0.000789042,0.00004105044,0.09228105,0.0003543732,0.0005303786,0.0002243487,0.00001186296,0.0006662427],"genre_scores_gemma":[0.9978095,0.000485301,0.0002247744,0.0004140484,0.0000879262,0.00001360774,0.00006278425,0.00003673226,0.0008653204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09270786,"threshold_uncertainty_score":0.9018396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02129982562793909,"score_gpt":0.2726101338208635,"score_spread":0.2513103081929244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}