{"id":"W2658185239","doi":"10.1016/j.cllc.2017.06.002","title":"Symptom and Quality of Life Improvement in LUX-Lung 8, an Open-Label Phase III Study of Second-Line Afatinib Versus Erlotinib in Patients With Advanced Squamous Cell Carcinoma of the Lung After First-Line Platinum-Based Chemotherapy","year":2017,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Royal Victoria Hospital; Kingston General Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","keywords":"Afatinib; Medicine; Erlotinib; Lung cancer; Internal medicine; Discontinuation; Adverse effect; Oncology; Quality of life (healthcare); Cancer; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001723682,0.001092896,0.001998554,0.0003133403,0.0003316541,0.0008648035,0.0007884323,0.00102974,0.002871456],"category_scores_gemma":[0.00118255,0.0004264548,0.001839168,0.000264468,0.0007642363,0.0007224039,0.0003103142,0.002402173,0.0004723019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008653393,"about_ca_system_score_gemma":0.0009125546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006625294,"about_ca_topic_score_gemma":0.001898958,"domain_scores_codex":[0.9993232,0.0003590603,0.00004230762,0.00009659057,0.00007503774,0.0001037874],"domain_scores_gemma":[0.9990333,0.0001783903,0.0002728204,0.00006041059,0.00006272082,0.0003923021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9223326,0.0275825,0.007496969,0.0004800218,0.001482602,0.00005786888,0.0001077837,0.0006242525,0.006371463,0.00006142653,0.0008688193,0.03253377],"study_design_scores_gemma":[0.7426414,0.2400592,0.01494357,0.00001714088,0.0004285382,0.00007404969,0.00002873671,0.0006874456,0.0007368303,0.00004971855,0.0003169926,0.00001642237],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975851,0.0009447164,0.0001237918,0.0001422972,0.00005148504,0.0004763,0.0002691754,0.00002615709,0.0003810244],"genre_scores_gemma":[0.9967324,0.0004496724,0.0003954107,0.0002877058,0.00009179962,0.0009248196,0.0005385635,0.000005334535,0.0005743603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002871456,"threshold_uncertainty_score":0.009605944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05280740285528082,"score_gpt":0.4378218886262724,"score_spread":0.3850144857709915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}