{"id":"W2658185239","doi":"10.1016/j.cllc.2017.06.002","title":"Symptom and Quality of Life Improvement in LUX-Lung 8, an Open-Label Phase III Study of Second-Line Afatinib Versus Erlotinib in Patients With Advanced Squamous Cell Carcinoma of the Lung After First-Line Platinum-Based Chemotherapy","year":2017,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Royal Victoria Hospital; Kingston General Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","keywords":"Afatinib; Medicine; Erlotinib; Lung cancer; Internal medicine; Discontinuation; Adverse effect; Oncology; Quality of life (healthcare); Cancer; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005143135,0.0002631235,0.001008851,0.00007113344,0.00008801442,0.00001818713,0.0003374113,0.0001139023,0.0001132398],"category_scores_gemma":[0.0001990905,0.0001787781,0.00006488663,0.0001515923,0.0002288584,0.0001859594,0.0001381781,0.000258217,8.080414e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001968325,"about_ca_system_score_gemma":0.0005488868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001869874,"about_ca_topic_score_gemma":0.01120485,"domain_scores_codex":[0.9972423,0.0001338967,0.001463337,0.0005350282,0.0003741158,0.0002513694],"domain_scores_gemma":[0.9969298,0.0003794706,0.001246748,0.0009983312,0.0002819229,0.0001636916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03716813,0.01521457,0.9419373,0.0004961569,0.0001660854,0.000002709612,0.001256409,0.000149537,0.0001105014,0.000002740795,0.00002402706,0.003471878],"study_design_scores_gemma":[0.2284702,0.008853774,0.7597796,0.0002686115,0.0003015579,2.432505e-8,0.0002272705,0.001416847,0.0005307451,0.000001483782,0.000006194282,0.0001437113],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940895,0.0004107353,0.000007482569,0.0001680566,0.0002840313,0.004615952,0.0002995995,0.000006630718,0.0001179792],"genre_scores_gemma":[0.998937,0.0000214192,0.000181871,0.0002285264,0.00005164882,0.000421403,0.00003972342,0.00003774798,0.00008067995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1913021,"threshold_uncertainty_score":0.7290359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05280740285528082,"score_gpt":0.4378218886262724,"score_spread":0.3850144857709915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}