{"id":"W2663054479","doi":"10.1016/j.vaccine.2017.06.024","title":"Process intensification for high yield production of influenza H1N1 Gag virus-like particles using an inducible HEK-293 stable cell line","year":2017,"lang":"en","type":"article","venue":"Vaccine","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Polytechnique Montréal; National Research Council Canada","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"HEK 293 cells; Cell culture; Transfection; Hemagglutinin (influenza); Virus-like particle; Flow cytometry; Bioreactor; Green fluorescent protein; Virus; Influenza A virus; Cell biology; Cell; Biology; Chemistry; Recombinant DNA; Virology; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001667666,0.0001274674,0.0001477717,0.00003972958,0.0002878763,0.00004358902,0.0001775864,0.0001089874,0.00001697909],"category_scores_gemma":[0.0002951738,0.0001148138,0.00005024156,0.00005101462,0.0000189512,0.00003508422,0.00006515648,0.00005346104,0.000001519135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009117703,"about_ca_system_score_gemma":0.00006497616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002803285,"about_ca_topic_score_gemma":0.0001035452,"domain_scores_codex":[0.9991014,0.00002136209,0.0002512944,0.0003619312,0.00008268431,0.0001813224],"domain_scores_gemma":[0.9985478,0.000005795897,0.0003120561,0.0006770678,0.0003940802,0.00006317801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003347474,0.0002900757,0.005652287,0.0001038609,0.00001993252,1.889051e-7,0.00005103644,0.001685891,0.989948,0.00001317968,0.001234509,0.0006662998],"study_design_scores_gemma":[0.000572884,0.0005446775,0.004054991,0.0000433518,0.00004058733,0.000002092887,0.00008151567,0.0005433235,0.9926456,0.0003615381,0.0009626152,0.0001467729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978235,0.0002779388,0.0009697605,0.00009202851,0.000422708,0.0003440851,0.00002961932,0.00001561384,0.0000246992],"genre_scores_gemma":[0.9985783,0.00005839133,0.0004838268,0.0001346626,0.0004513082,0.0000504139,0.0000678553,0.00002380204,0.0001514341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002697659,"threshold_uncertainty_score":0.4681972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05868615824990077,"score_gpt":0.3335136126746445,"score_spread":0.2748274544247437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}