{"id":"W2663054479","doi":"10.1016/j.vaccine.2017.06.024","title":"Process intensification for high yield production of influenza H1N1 Gag virus-like particles using an inducible HEK-293 stable cell line","year":2017,"lang":"en","type":"article","venue":"Vaccine","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Polytechnique Montréal; National Research Council Canada","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"HEK 293 cells; Cell culture; Transfection; Hemagglutinin (influenza); Virus-like particle; Flow cytometry; Bioreactor; Green fluorescent protein; Virus; Influenza A virus; Cell biology; Cell; Biology; Chemistry; Recombinant DNA; Virology; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002863314,0.000414788,0.0003740262,0.0001971153,0.0002112244,0.0004513818,0.0002555224,0.0002610472,0.001114489],"category_scores_gemma":[0.0001643949,0.0002001283,0.0004630527,0.0003150375,0.000158914,0.0002739149,0.0002484446,0.0008605816,0.0007028335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000248129,"about_ca_system_score_gemma":0.0002294128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004578653,"about_ca_topic_score_gemma":0.0006742059,"domain_scores_codex":[0.9998172,0.00001978231,0.0000201145,0.00004642341,0.00006262353,0.00003396668],"domain_scores_gemma":[0.9999248,0.00002324937,0.00001908626,0.00001190718,0.00001368798,0.000007287663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000181437,0.00001337391,0.00004336305,0.00001463226,0.000001660647,0.00001489352,0.00000867558,0.00003699469,0.9990959,0.00004116309,0.00001488415,0.0006963696],"study_design_scores_gemma":[0.000003797134,0.00003661364,0.0004239655,0.00000138781,0.000007611826,0.00004015546,0.000005159687,0.0004702893,0.99803,0.00001857885,0.0009601451,0.000002297666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8783618,0.000975134,0.115154,0.0001562291,0.00009740098,0.0003163764,0.00110437,0.0006558572,0.003178881],"genre_scores_gemma":[0.8892113,0.001403263,0.09921362,0.0001189692,0.00003049146,0.0003318064,0.00260247,0.000293005,0.006794973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001114489,"threshold_uncertainty_score":0.00372833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05868615824990077,"score_gpt":0.3335136126746445,"score_spread":0.2748274544247437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}