{"id":"W2667726975","doi":"10.1186/s40478-017-0448-2","title":"Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice","year":2017,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FP7 People: Marie-Curie Actions; Leibniz-Gemeinschaft; Academy of Finland; Norges Forskningsråd; ZonMw; Austrian Science Fund; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; European Commission; State Education Development Agency Republic of Latvia; Canadian Institutes of Health Research; EU Joint Programme – Neurodegenerative Disease Research","keywords":"Genetically modified mouse; Endogeny; Transgene; Neuroscience; Amyloid (mycology); Neurology; Amyloid precursor protein; Cell biology; Amyloid β; Biology; Medicine; Endocrinology; Internal medicine; Alzheimer's disease; Disease; Gene; Pathology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004873631,0.0007134333,0.0005042619,0.0009840501,0.0003203172,0.000560648,0.0005137278,0.0007930229,0.002375707],"category_scores_gemma":[0.0002527784,0.0004236975,0.0004725429,0.0003333178,0.0005276531,0.0004845564,0.0004203644,0.001281564,0.001526565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002641079,"about_ca_system_score_gemma":0.0002282894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003375389,"about_ca_topic_score_gemma":0.0004964737,"domain_scores_codex":[0.9995967,0.00006942661,0.00007126048,0.0001013697,0.00007932194,0.00008196229],"domain_scores_gemma":[0.9995617,0.00004806883,0.0001366815,0.00006460181,0.00004375899,0.0001451845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003254553,0.0001552715,0.0002095798,0.00005212845,0.000009496727,0.0001667137,0.00005317672,0.00003553641,0.9978476,0.0001813307,0.00006796536,0.000895819],"study_design_scores_gemma":[0.0002632269,0.002625598,0.01085612,0.00009011671,0.000114911,0.001862116,0.0001731017,0.001240599,0.9719996,0.0005429154,0.01020064,0.00003108332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98655,0.001844281,0.006542844,0.0002208057,0.0001603428,0.0002006423,0.001585504,0.0003268782,0.002568699],"genre_scores_gemma":[0.9718151,0.004508537,0.01155239,0.000211697,0.0001114804,0.0006990377,0.002978563,0.0002693196,0.007853949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002375707,"threshold_uncertainty_score":0.007947564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09054455300793686,"score_gpt":0.3336974809120663,"score_spread":0.2431529279041295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}