{"id":"W2667726975","doi":"10.1186/s40478-017-0448-2","title":"Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice","year":2017,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FP7 People: Marie-Curie Actions; Leibniz-Gemeinschaft; Academy of Finland; Norges Forskningsråd; ZonMw; Austrian Science Fund; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; European Commission; State Education Development Agency Republic of Latvia; Canadian Institutes of Health Research; EU Joint Programme – Neurodegenerative Disease Research","keywords":"Genetically modified mouse; Endogeny; Transgene; Neuroscience; Amyloid (mycology); Neurology; Amyloid precursor protein; Cell biology; Amyloid β; Biology; Medicine; Endocrinology; Internal medicine; Alzheimer's disease; Disease; Gene; Pathology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001599427,0.0001470429,0.0002593605,0.000114227,0.0005150331,0.0000337476,0.0008498351,0.00006814139,0.00002276842],"category_scores_gemma":[0.0002520747,0.0001217645,0.0001089583,0.00008418037,0.000343498,0.0001749929,0.0003986366,0.0002818228,0.00002429528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003132368,"about_ca_system_score_gemma":0.00007078086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008516908,"about_ca_topic_score_gemma":0.00001918593,"domain_scores_codex":[0.9987172,0.0002817402,0.0002966021,0.0002544143,0.0002030715,0.0002469222],"domain_scores_gemma":[0.9965162,0.0001475484,0.0001911732,0.002865761,0.000104313,0.0001749716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002518324,0.001663741,0.0366294,0.0000362418,0.00008987926,0.000120568,0.0001947171,0.000004936143,0.9600474,0.00006980753,0.0000230811,0.0008684488],"study_design_scores_gemma":[0.002910418,0.000595057,0.6411095,0.0002674525,0.0003429345,0.0001768109,0.0001121406,0.0006227486,0.353036,0.0003623813,0.0001910127,0.0002735794],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920242,0.002566277,0.00002405866,0.001371859,0.00001859078,0.0006162925,0.00005457846,0.00006380156,0.00326031],"genre_scores_gemma":[0.9937732,0.003930558,0.001913991,0.0000680927,0.00001375414,0.0001210808,0.0001309749,0.00002136435,0.00002697611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6070113,"threshold_uncertainty_score":0.4965412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09054455300793686,"score_gpt":0.3336974809120663,"score_spread":0.2431529279041295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}