{"id":"W2668594481","doi":"10.1084/jem.20170844","title":"Thymic progenitors of TCRαβ+ CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development","year":2017,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; BC Children's Hospital; University of Alberta; Child and Family Research Institute; Alberta Innovates - Health Solutions; University of British Columbia; Canadian Donation and Transplantation Research Program","keywords":"T-cell receptor; Biology; Thymocyte; Intraepithelial lymphocyte; CD8; Cell biology; Progenitor; Negative selection; Clonal deletion; Progenitor cell; Cell fate determination; T cell; Immunology; Genetics; Antigen; Stem cell; Transcription factor; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007413115,0.0002525907,0.0001541786,0.0001548156,0.0001503856,0.0003778194,0.0001607407,0.0001938459,0.001053121],"category_scores_gemma":[0.00009284938,0.0001141524,0.0001499474,0.00009761352,0.0001802869,0.0001853256,0.0003258615,0.0006779549,0.0006509087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000132981,"about_ca_system_score_gemma":0.0001437736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001169135,"about_ca_topic_score_gemma":0.0002557566,"domain_scores_codex":[0.9998649,0.00001673988,0.00001134346,0.00002426189,0.00003986875,0.00004286169],"domain_scores_gemma":[0.9998627,0.00001464166,0.00004291714,0.00002072323,0.00001127488,0.0000477607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003928568,0.00000742705,0.0003612212,0.0000103833,0.000001142719,0.00006413416,0.00001522216,0.00001729206,0.9982545,0.0000749918,0.00000949742,0.001144868],"study_design_scores_gemma":[0.000009868555,0.0001451948,0.01495273,0.000009126782,0.00001386515,0.001008021,0.00011044,0.0003955281,0.9809579,0.0001053106,0.002288664,0.000003487249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958767,0.0003980851,0.001922046,0.00003884856,0.000009055231,0.00001237545,0.0001408094,0.0000649594,0.001537184],"genre_scores_gemma":[0.9960558,0.0002879913,0.001392927,0.00001775542,0.000006161334,0.00001533119,0.0002824116,0.00001669388,0.00192491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001053121,"threshold_uncertainty_score":0.003523052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03607443403196664,"score_gpt":0.3192790497111637,"score_spread":0.2832046156791971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}