{"id":"W2668662280","doi":"10.1128/jb.00344-17","title":"The Proline Variant of the W[F/L/M][T/S]R Cyclic Di-GMP Binding Motif Suppresses Dependence on Signal Association for Regulator Function","year":2017,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alcon (Canada)","funders":"Indiana University Bloomington","keywords":"Biology; Vibrio vulnificus; Operon; Mutant; Regulator; Activator (genetics); Binding site; Biochemistry; Molecular biology; Cell biology; Gene; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001308888,0.0002314634,0.0001776472,0.0001077858,0.0001015803,0.0001760832,0.0003278446,0.0001997312,0.00157194],"category_scores_gemma":[0.0001657558,0.00009037712,0.0002123044,0.00008122043,0.0001910212,0.00007000269,0.000151931,0.0004526702,0.0006265136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001989112,"about_ca_system_score_gemma":0.0001691256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007509695,"about_ca_topic_score_gemma":0.0009146708,"domain_scores_codex":[0.9998462,0.00003678066,0.000016925,0.00002705114,0.00003440808,0.00003858236],"domain_scores_gemma":[0.9997297,0.00006397975,0.00006515541,0.00003569857,0.00002309837,0.00008224712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006907107,0.00001779768,0.00005047442,0.000005620407,0.000001550457,0.00002579629,0.000002749684,0.00002700864,0.9995282,0.00002425876,0.00001352313,0.0002339692],"study_design_scores_gemma":[0.00002546947,0.0003648195,0.002711359,0.000005637325,0.000007783613,0.0001959969,0.00001411545,0.001844603,0.9934534,0.00002350981,0.001347698,0.000005674911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965746,0.0001661527,0.002127501,0.00004931393,0.00001942549,0.00002137733,0.0002244629,0.00007294989,0.0007440581],"genre_scores_gemma":[0.9970175,0.00004668494,0.001490845,0.00004620321,0.000007199675,0.00001532754,0.0003790107,0.00004730597,0.0009498376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00157194,"threshold_uncertainty_score":0.005258679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01571752163434477,"score_gpt":0.2812837686204249,"score_spread":0.2655662469860802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}