{"id":"W266986211","doi":"10.1016/j.ijpara.2015.03.010","title":"Ivermectin binds to Haemonchus contortus tubulins and promotes stability of microtubules","year":2015,"lang":"en","type":"article","venue":"International Journal for Parasitology","topic":"Helminth infection and control","field":"Veterinary","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Haemonchus contortus; Ivermectin; Biology; Anthelmintic; Microtubule; Parasite hosting; Helminths; Tubulin; Zoology; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001676224,0.000333507,0.0002266601,0.0003924486,0.0004549853,0.0003903154,0.0002503321,0.0003498624,0.00442131],"category_scores_gemma":[0.0003127604,0.0002758605,0.0004342077,0.0001713837,0.0001517353,0.0002380716,0.0002510616,0.0004239583,0.0005953208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007540373,"about_ca_system_score_gemma":0.0002887319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003618823,"about_ca_topic_score_gemma":0.006664031,"domain_scores_codex":[0.9998255,0.00002811431,0.000008472417,0.00003154586,0.00003496287,0.00007143249],"domain_scores_gemma":[0.9998672,0.00001643398,0.00003550654,0.000007161271,0.00004145407,0.00003214271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001442404,0.00003807989,0.0009266971,0.0001670467,0.00005424036,0.00006749491,0.00002146395,0.0001223432,0.9921651,0.0002078736,0.0008025514,0.005282758],"study_design_scores_gemma":[0.0000589753,0.0005817918,0.0543755,0.00007934496,0.00007398995,0.0003814858,0.0000969751,0.001270073,0.9168785,0.000167907,0.02601959,0.00001582849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648214,0.0134563,0.004285801,0.001052864,0.0002855208,0.00007343417,0.0004099592,0.0002019445,0.01541284],"genre_scores_gemma":[0.9767496,0.004522825,0.001484371,0.0004433351,0.00005730995,0.00002765929,0.0006913227,0.00003692566,0.01598679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00442131,"threshold_uncertainty_score":0.01479077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1139512589707128,"score_gpt":0.4290448689456996,"score_spread":0.3150936099749868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}