{"id":"W266986211","doi":"10.1016/j.ijpara.2015.03.010","title":"Ivermectin binds to Haemonchus contortus tubulins and promotes stability of microtubules","year":2015,"lang":"en","type":"article","venue":"International Journal for Parasitology","topic":"Helminth infection and control","field":"Veterinary","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Haemonchus contortus; Ivermectin; Biology; Anthelmintic; Microtubule; Parasite hosting; Helminths; Tubulin; Zoology; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000446423,0.0001114748,0.0002467516,0.0001637099,0.00005682871,0.00003931228,0.000199816,0.00008968082,0.0001062402],"category_scores_gemma":[0.0007566035,0.00009980302,0.00009083666,0.0000430276,0.00007741252,0.0001035354,0.00005039725,0.0001402528,0.00002232693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001009162,"about_ca_system_score_gemma":0.0001172332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000105823,"about_ca_topic_score_gemma":0.0001020715,"domain_scores_codex":[0.9989541,0.0001020153,0.0004057481,0.0001755697,0.0001833624,0.0001792591],"domain_scores_gemma":[0.9985495,0.0001875824,0.0001782032,0.00009144399,0.0007823008,0.0002110256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01417593,0.001034345,0.7037542,0.00004919828,0.001363937,0.0005419186,0.005935439,0.00003107282,0.1781193,0.006717113,0.010926,0.07735155],"study_design_scores_gemma":[0.0243748,0.02146414,0.4801022,0.0002213771,0.0002695306,0.03753141,0.003413132,0.00292313,0.1239813,0.02079201,0.2835264,0.001400515],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989713,0.00008779229,0.004153605,0.002465355,0.002409088,0.0002696047,0.00006750236,0.00002074162,0.0008132824],"genre_scores_gemma":[0.9983109,0.000006032531,0.0009359893,0.0002590178,0.0003666503,0.00002744347,0.000005780769,0.00001010401,0.00007810381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2726004,"threshold_uncertainty_score":0.4069849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1139512589707128,"score_gpt":0.4290448689456996,"score_spread":0.3150936099749868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}