{"id":"W2671688469","doi":"10.1038/ncomms15936","title":"Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":262,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Medical Research Council; University College London Hospitals NHS Foundation Trust; CHILDREN with CANCER UK; Rosetrees Trust; Wellcome Trust; Francis Crick Institute; Cancer Research UK; National Institute for Health and Care Research; St. Baldrick's Foundation","keywords":"Osteosarcoma; Biology; Mutation; Cancer research; Gene duplication; Insulin-like growth factor 1 receptor; Genetics; Gene; Malignancy; Growth factor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001377644,0.00007229203,0.0001920868,0.00008056024,0.0001005693,0.00001032056,0.0002466502,0.00007206637,0.000008891447],"category_scores_gemma":[0.0001006011,0.00006241259,0.00004509587,0.000029857,0.00007544338,0.00003686235,0.0001681329,0.0001840979,8.35448e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005399621,"about_ca_system_score_gemma":0.00003400914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002507327,"about_ca_topic_score_gemma":0.001815033,"domain_scores_codex":[0.999438,0.00004717215,0.0002398206,0.0001041278,0.0001003536,0.00007053983],"domain_scores_gemma":[0.9984785,0.0001581568,0.0002198966,0.001001378,0.0001103814,0.00003165371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003163001,0.0005550865,0.9231606,0.00006985051,0.00005517546,0.000004379493,0.0003752724,0.000001495714,0.003987487,0.0009492783,0.00001429042,0.07079552],"study_design_scores_gemma":[0.0009068749,0.00009755057,0.9945251,0.0002397804,0.00008927416,0.000006467584,0.0001321621,0.0002021056,0.003099319,0.0001227289,0.0005316765,0.00004698428],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747411,0.02202701,0.00001360878,0.002489199,0.00003403964,0.0003360236,0.00003888322,0.000005476533,0.0003146335],"genre_scores_gemma":[0.995198,0.002949264,0.001667187,0.00002007117,0.00001209386,0.0000489085,0.00009041279,0.000007609922,0.000006445873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07136454,"threshold_uncertainty_score":0.2545111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04436947049937238,"score_gpt":0.3433156145243396,"score_spread":0.2989461440249672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}