{"id":"W2673193175","doi":"10.1016/j.molmet.2017.06.012","title":"Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes","year":2017,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Glucagon receptor; Internal medicine; Endocrinology; Diabetes mellitus; Glucagon; Glucose homeostasis; Leptin; Leptin receptor; Streptozotocin; Insulin; Carbohydrate metabolism; Lipid metabolism; Medicine; Receptor; Chemistry; Insulin resistance; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003902414,0.0008813659,0.0006286144,0.0007985557,0.0002033946,0.0003818057,0.0003228915,0.0006708973,0.001247796],"category_scores_gemma":[0.0001438367,0.0002199326,0.000473687,0.0003055301,0.0003197381,0.0004141976,0.0001974038,0.001109348,0.0004054356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003943162,"about_ca_system_score_gemma":0.0002943694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005389644,"about_ca_topic_score_gemma":0.0006881731,"domain_scores_codex":[0.9997029,0.00004363964,0.00004161463,0.0000714304,0.00008219291,0.00005817533],"domain_scores_gemma":[0.9998273,0.00001835073,0.00005994253,0.00001436908,0.00002644084,0.00005359288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007570984,0.0002515938,0.00009172807,0.00007068882,0.00001269423,0.00003818453,0.0000179266,0.00009113766,0.9961463,0.00006122125,0.00011576,0.002345642],"study_design_scores_gemma":[0.0001395101,0.001848101,0.001009036,0.00001179343,0.0000483931,0.00009543485,0.00001958169,0.0008411573,0.9947268,0.00003435985,0.001218207,0.000007563935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840664,0.002611981,0.008149261,0.0004825434,0.0002609186,0.000133579,0.0006729742,0.0007084939,0.002913892],"genre_scores_gemma":[0.9767644,0.003106275,0.01077575,0.0002906758,0.00005445228,0.0003410884,0.001178271,0.000174968,0.007314057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001247796,"threshold_uncertainty_score":0.004174292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01454247377562067,"score_gpt":0.2403251561949677,"score_spread":0.225782682419347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}