{"id":"W2676635625","doi":"10.3168/jds.2015-10729","title":"Combination of histidine, lysine, methionine, and leucine promotes β-casein synthesis via the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells","year":2017,"lang":"en","type":"article","venue":"Journal of Dairy Science","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agricultural Science and Technology Innovation Program; University of Manitoba","keywords":"Ribosomal protein s6; Casein; P70-S6 Kinase 1; PI3K/AKT/mTOR pathway; Phosphorylation; Ribosomal protein; Casein kinase 1; Leucine; Casein kinase 2; Western blot; Signal transduction; Methionine; Biology; Biochemistry; Chemistry; Protein kinase A; Amino acid; Ribosome; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002743505,0.0002756907,0.0004931798,0.0001672174,0.0001040807,0.0003346852,0.0001524813,0.0002085211,0.0004576216],"category_scores_gemma":[0.0001199852,0.0001745755,0.0003863351,0.0001576566,0.0001351499,0.0001187225,0.0001876589,0.0002992293,0.0001571943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002259687,"about_ca_system_score_gemma":0.0002010586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005401241,"about_ca_topic_score_gemma":0.001017882,"domain_scores_codex":[0.9996622,0.00007210795,0.00004156942,0.00006407918,0.0001062717,0.00005382403],"domain_scores_gemma":[0.9999088,0.000019475,0.00003036663,0.000007210356,0.0000152753,0.00001890415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001258636,0.00002284759,0.00007775716,0.00003734631,0.000004334019,0.00001036703,0.000007390724,0.00005906574,0.9991153,0.000007984879,0.0000122436,0.0005195164],"study_design_scores_gemma":[0.00001776719,0.001074711,0.004304832,0.000006038793,0.00002414658,0.00005725138,0.00003686714,0.001140176,0.9922171,0.00001376721,0.001100035,0.000007307707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963915,0.001377419,0.001316533,0.00004835357,0.00002912301,0.00001922494,0.0001211958,0.00003228405,0.0006644398],"genre_scores_gemma":[0.9953486,0.0007491395,0.002779682,0.00005850185,0.000007590666,0.00003905595,0.0001930489,0.000009875362,0.0008144987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005401241,"threshold_uncertainty_score":0.001639605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235783936674338,"score_gpt":0.2440546277341738,"score_spread":0.2316967883674304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}