{"id":"W2677331635","doi":"10.2217/pgs-2017-0035","title":"Rationale and Design of the Multiethnic Pharmacogenomics in Childhood Asthma Consortium","year":2017,"lang":"en","type":"article","venue":"Pharmacogenomics","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Stockholms Läns Landsting; Stichting Astma Bestrijding; Hjärt-Lungfonden; National Institutes of Health; National Heart, Lung, and Blood Institute; Vetenskapsrådet; Karolinska Institutet; Lundbeckfonden; European Commission; Instituto de Salud Carlos III; National Institute for Health and Care Research","keywords":"Pharmacogenomics; Asthma; Medicine; Pharmacogenetics; Pharmacology; Internal medicine; Genetics; Biology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1518762,0.002151641,0.001820361,0.003694043,0.00554464,0.004682182,0.005770267,0.003282027,0.0110004],"category_scores_gemma":[0.108689,0.001674075,0.002197128,0.006261239,0.003893781,0.002726249,0.008855086,0.004075315,0.002801657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004838765,"about_ca_system_score_gemma":0.0293337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01031901,"about_ca_topic_score_gemma":0.01181144,"domain_scores_codex":[0.8394428,0.1271459,0.01005707,0.008358659,0.01133582,0.003659665],"domain_scores_gemma":[0.9260153,0.0176671,0.01223849,0.01446397,0.01835338,0.01126178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.06127489,0.005667026,0.2857181,0.01205633,0.00640481,0.00375874,0.01275326,0.010849,0.005077131,0.1697069,0.1625006,0.2642332],"study_design_scores_gemma":[0.05096318,0.01149321,0.2360941,0.01134391,0.005234631,0.002654399,0.00687247,0.01467634,0.007015728,0.05543483,0.5973476,0.0008695504],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.04844478,0.005139671,0.1061577,0.02330617,0.003411364,0.7674033,0.0225525,0.0005877207,0.02299688],"genre_scores_gemma":[0.06278955,0.0007561758,0.1238292,0.004071576,0.0007472749,0.8013258,0.004494057,0.00007098627,0.00191533],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1518762,"threshold_uncertainty_score":0.8032079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03918140219364531,"score_gpt":0.3134116984605302,"score_spread":0.2742302962668849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}