{"id":"W2680122361","doi":"10.1016/j.molimm.2017.06.025","title":"IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation","year":2017,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre","funders":"Canadian Cancer Society","keywords":"Interleukin 12; Ex vivo; Interleukin 21; IL-2 receptor; Janus kinase 3; Interleukin 15; STAT4; Cell biology; Stimulation; Biology; T cell; In vivo; Immunology; Chemistry; Interleukin; Cytokine; Cytotoxic T cell; Immune system; In vitro; Signal transduction; Endocrinology; STAT3; stat; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003235021,0.0004816155,0.0005882026,0.000321332,0.0008406604,0.0001328065,0.000456607,0.000772866,0.001024744],"category_scores_gemma":[0.0005653822,0.0004886913,0.000104154,0.0001918035,0.0002874164,0.0005179202,0.0002656131,0.0007619637,0.0005410631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001422826,"about_ca_system_score_gemma":0.00009837636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004845432,"about_ca_topic_score_gemma":0.00004724919,"domain_scores_codex":[0.9971147,0.0004868723,0.0005939302,0.001003019,0.0001010061,0.0007004635],"domain_scores_gemma":[0.9977783,0.00006532143,0.0005725255,0.00111741,0.0004162221,0.00005022379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001668872,0.000205744,0.00002010906,0.00002282016,0.0004904357,0.000005916103,0.0009214011,0.000007208522,0.975844,0.00004957313,0.01412577,0.006638206],"study_design_scores_gemma":[0.00168257,0.0007635713,0.001806191,0.0000597869,0.00006468326,0.00008684548,0.000355309,0.000005613427,0.9318821,0.00004210557,0.06278596,0.0004652129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881873,0.0003782659,0.001948904,0.002862329,0.004613643,0.0008471048,0.00003371104,0.0001680209,0.0009607844],"genre_scores_gemma":[0.9838793,0.0002147395,0.00007747172,0.0009102966,0.00005245499,0.0001871336,0.0002615506,0.00006455508,0.0143525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04866019,"threshold_uncertainty_score":0.9998885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110134687077729,"score_gpt":0.2378245004235413,"score_spread":0.2268110317157684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}