{"id":"W2680122361","doi":"10.1016/j.molimm.2017.06.025","title":"IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation","year":2017,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre","funders":"Canadian Cancer Society","keywords":"Interleukin 12; Ex vivo; Interleukin 21; IL-2 receptor; Janus kinase 3; Interleukin 15; STAT4; Cell biology; Stimulation; Biology; T cell; In vivo; Immunology; Chemistry; Interleukin; Cytokine; Cytotoxic T cell; Immune system; In vitro; Signal transduction; Endocrinology; STAT3; stat; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002048265,0.0006284725,0.0005026349,0.0001989658,0.0001095323,0.0004286203,0.0001330096,0.0002731073,0.002198674],"category_scores_gemma":[0.0001239849,0.0001675006,0.0004482891,0.0001225141,0.0002552823,0.0002864966,0.000275181,0.001412645,0.0007392062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001839764,"about_ca_system_score_gemma":0.0002521769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000181965,"about_ca_topic_score_gemma":0.0004393179,"domain_scores_codex":[0.9996864,0.0000563976,0.00003856472,0.00004497665,0.00005913846,0.000114544],"domain_scores_gemma":[0.9997945,0.00004523417,0.00004742435,0.00004136339,0.00001330048,0.0000581486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006988508,0.00008361589,0.0003739044,0.0000368557,0.000007135399,0.00009248596,0.00001582665,0.00008596176,0.9971684,0.00003659885,0.00004384639,0.001356645],"study_design_scores_gemma":[0.00006861163,0.0008836612,0.007635983,0.00001121997,0.00003219985,0.0003972173,0.00005360501,0.0005057515,0.9891815,0.00005087622,0.001173079,0.000006289097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966995,0.0007576095,0.0009745719,0.00006514489,0.00008138268,0.000024259,0.0004304719,0.00006205135,0.0009049905],"genre_scores_gemma":[0.9967258,0.0002905749,0.0009694148,0.00004463239,0.00002390226,0.00002771283,0.0005127416,0.0000168133,0.001388385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002198674,"threshold_uncertainty_score":0.007355273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110134687077729,"score_gpt":0.2378245004235413,"score_spread":0.2268110317157684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}