{"id":"W2686521530","doi":"10.15252/emmm.201607471","title":"REST suppression mediates neural conversion of adult human fibroblasts via microRNA‐dependent and ‐independent pathways","year":2017,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Medical Research Council; Canadian Institutes of Health Research; Stiftelsen för Strategisk Forskning; Parkinsonfonden; Lunds Universitet; Vetenskapsrådet; University of Cambridge; New York Stem Cell Foundation; Stiftelsen för Strategisk Forskning; Stockholms Läns Landsting; National Institute for Health and Care Research; Karolinska Institutet; European Commission","keywords":"Reprogramming; Gene knockdown; Rest (music); RNA; Biology; Small interfering RNA; microRNA; Cell biology; Gene; Medicine; Genetics; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003143787,0.0002487828,0.0003273092,0.00009644746,0.0002708783,0.00002655206,0.0005622068,0.0002174357,0.00005976509],"category_scores_gemma":[0.0002801561,0.0002045024,0.00007824695,0.00003324123,0.000496301,0.00001125668,0.0006733254,0.0002084293,0.000006810919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001664874,"about_ca_system_score_gemma":0.00003654584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002621952,"about_ca_topic_score_gemma":0.000036908,"domain_scores_codex":[0.9980016,0.0001304118,0.0003584824,0.0005519252,0.0005924792,0.0003650986],"domain_scores_gemma":[0.9982672,0.00001879606,0.0002901067,0.0009469416,0.0002246263,0.0002523032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001322172,0.00005328426,0.002664136,0.000140608,0.00005071741,0.0001309767,0.00007993429,0.000008267395,0.9954779,0.00002951861,0.0007427057,0.0004897911],"study_design_scores_gemma":[0.002420882,0.0008196423,0.01895786,0.0001823378,0.00003722212,0.0000619456,0.00007416112,0.0002000177,0.9765641,0.00007469855,0.0004083187,0.0001988082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960788,0.001140533,0.0003634453,0.0008469695,0.0002286158,0.0003194406,0.00002283912,0.00001048472,0.0009888372],"genre_scores_gemma":[0.9987227,0.0003223596,0.00009079679,0.0001421716,0.000169894,0.000009697944,0.000203038,0.00003501002,0.0003042856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01891374,"threshold_uncertainty_score":0.8339364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01248938068622055,"score_gpt":0.2716416589458425,"score_spread":0.259152278259622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}