{"id":"W2687206218","doi":"10.1371/journal.pbio.2001930","title":"MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression","year":2017,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Superantigen; Biology; Immunology; Population; Cytokine; Cytokine storm; Tumor necrosis factor alpha; Immune system; Streptococcus pyogenes; Toxic shock syndrome; T cell; Microbiology; Staphylococcus aureus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006455176,0.0004483457,0.0007595786,0.0002484751,0.001043783,0.0000992036,0.0002982329,0.0006370752,0.0004580971],"category_scores_gemma":[0.0001758688,0.0003782461,0.00008243815,0.00005225294,0.0006100525,0.0003765199,0.0004717792,0.0003754113,0.00003384225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002497154,"about_ca_system_score_gemma":0.00007592675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002215447,"about_ca_topic_score_gemma":0.00005431768,"domain_scores_codex":[0.9974735,0.0006535124,0.0005261756,0.0007734862,0.00003849916,0.0005348603],"domain_scores_gemma":[0.9985217,0.0002613582,0.0003340182,0.000654117,0.0001527222,0.00007611074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01158466,0.0001720784,0.002316714,0.00005305039,0.0002075904,0.000006565703,0.001447903,4.533618e-7,0.9817114,0.0002951378,0.00003764543,0.002166769],"study_design_scores_gemma":[0.004262427,0.00277942,0.0593627,0.0001310489,0.0001235257,0.0004621549,0.0009405154,0.00003306154,0.9279163,0.00003373607,0.003446016,0.0005090818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944933,0.001129692,0.0001835101,0.0002020051,0.003260461,0.0004476453,0.0001385815,0.00007301535,0.00007178641],"genre_scores_gemma":[0.9986318,0.0004732754,0.0001951326,0.0001453485,0.00007118268,0.00002881982,0.0002052835,0.00004715893,0.000202023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05704598,"threshold_uncertainty_score":0.999867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02711517603963177,"score_gpt":0.2302080413616596,"score_spread":0.2030928653220278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}