{"id":"W2687206218","doi":"10.1371/journal.pbio.2001930","title":"MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression","year":2017,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Superantigen; Biology; Immunology; Population; Cytokine; Cytokine storm; Tumor necrosis factor alpha; Immune system; Streptococcus pyogenes; Toxic shock syndrome; T cell; Microbiology; Staphylococcus aureus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001694948,0.0002957165,0.0001843024,0.0001918485,0.000158027,0.000401756,0.0001364139,0.0002341021,0.001555345],"category_scores_gemma":[0.0001538494,0.00009143879,0.0001955652,0.0001226031,0.0002354708,0.0002621428,0.000295844,0.0006553302,0.000360758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005847644,"about_ca_system_score_gemma":0.0001053173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008441101,"about_ca_topic_score_gemma":0.0001212337,"domain_scores_codex":[0.9998901,0.00002141803,0.00001645611,0.00002848745,0.00001839324,0.00002517892],"domain_scores_gemma":[0.9998907,0.00002061911,0.00002589351,0.00002238839,0.00001041951,0.00003002344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003324972,0.00004962732,0.002541974,0.00005882435,0.000004121787,0.0004227258,0.00009879874,0.00006906649,0.9918033,0.0002319786,0.00003676071,0.004350326],"study_design_scores_gemma":[0.0001021339,0.003419854,0.02825087,0.00003949534,0.00004925462,0.008588713,0.0003449938,0.001437231,0.9494504,0.0004911238,0.007804902,0.00002107049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927938,0.001069408,0.004337479,0.00007036262,0.00002297742,0.0000503734,0.0001729689,0.00007341171,0.001409286],"genre_scores_gemma":[0.9939941,0.0006757218,0.003611678,0.00008877947,0.00004449869,0.00005214027,0.0002097137,0.00001047236,0.001312909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001555345,"threshold_uncertainty_score":0.005203187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02711517603963177,"score_gpt":0.2302080413616596,"score_spread":0.2030928653220278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}