{"id":"W2687319114","doi":"10.3851/imp3181","title":"Long-Term Persistence of HCV NS5A Resistance-Associated Substitutions after Treatment with the HCV NS5A Inhibitor, Ledipasvir, without Sofosbuvir","year":2017,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Ledipasvir; NS5A; Daclatasvir; Viral quasispecies; Sofosbuvir; Medicine; Population; Internal medicine; Virology; Gastroenterology; Hepatitis C virus; Ribavirin; Hepacivirus; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001076158,0.0001330866,0.000341804,0.0001846209,0.0004350386,0.0004698318,0.0001673764,0.0002600123,0.0007583072],"category_scores_gemma":[0.001593553,0.0001199028,0.0001626066,0.0002374939,0.0002792205,0.0004097235,0.0002582282,0.0005607883,0.0001650072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003653242,"about_ca_system_score_gemma":0.0002688363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001299747,"about_ca_topic_score_gemma":0.001511283,"domain_scores_codex":[0.9996181,0.0000745658,0.00003640964,0.0001076772,0.00008145015,0.00008171023],"domain_scores_gemma":[0.9982292,0.0003506622,0.0008474215,0.0001395828,0.0001877192,0.00024549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002081174,0.0002855797,0.9508568,0.00005788755,0.00009969835,0.0003889209,0.0004505935,0.0001974447,0.02440852,0.00003728469,0.000157946,0.02097817],"study_design_scores_gemma":[0.00002682549,0.002469379,0.9911196,0.00001180942,0.00007634391,0.001051928,0.0002019733,0.0004549598,0.004128995,0.00003491148,0.0004141504,0.000009266161],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995659,0.0001506489,0.00005954369,0.0000161735,0.000001539963,0.000004015968,0.00005465949,0.000002193259,0.0001453462],"genre_scores_gemma":[0.9996574,0.00003150082,0.00004948152,0.00001770487,0.000003207251,0.00000344562,0.0001128712,0.0000011114,0.0001233509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001299747,"threshold_uncertainty_score":0.00569135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06577570250110594,"score_gpt":0.3395817990491626,"score_spread":0.2738060965480567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}