{"id":"W2687319114","doi":"10.3851/imp3181","title":"Long-Term Persistence of HCV NS5A Resistance-Associated Substitutions after Treatment with the HCV NS5A Inhibitor, Ledipasvir, without Sofosbuvir","year":2017,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Ledipasvir; NS5A; Daclatasvir; Viral quasispecies; Sofosbuvir; Medicine; Population; Internal medicine; Virology; Gastroenterology; Hepatitis C virus; Ribavirin; Hepacivirus; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003593444,0.0003261311,0.0005555886,0.0001065337,0.0006869077,0.0001255888,0.0003665634,0.0001489213,0.0001295417],"category_scores_gemma":[0.00007857424,0.0001896144,0.0002358149,0.0001943079,0.00122586,0.0003292049,0.00005828363,0.0003011668,0.0000662233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000239053,"about_ca_system_score_gemma":0.0003644557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004228883,"about_ca_topic_score_gemma":0.00480932,"domain_scores_codex":[0.997774,0.0001803344,0.0003100091,0.0004483865,0.0007256799,0.0005615605],"domain_scores_gemma":[0.9979759,0.00009535555,0.0002699826,0.001240437,0.0002885734,0.0001297902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002514718,0.0006484215,0.959324,0.00003258306,0.0005386946,0.0002631222,0.001324441,2.16094e-7,0.006483415,0.00007319594,0.0003626905,0.02843452],"study_design_scores_gemma":[0.00584147,0.001690075,0.9636583,0.0005275412,0.0001398967,0.000004486205,0.0001209696,0.00001705409,0.0162508,0.00002227222,0.01142369,0.0003034617],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98209,0.001350667,0.00004743236,0.00245381,0.0001141445,0.001013146,0.00007003692,0.00005670363,0.01280407],"genre_scores_gemma":[0.9871622,0.003007683,0.0001021624,0.0001630783,0.0001785083,0.0001724341,0.00002408326,0.00004898194,0.009140922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02813106,"threshold_uncertainty_score":0.7732251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06577570250110594,"score_gpt":0.3395817990491626,"score_spread":0.2738060965480567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}