{"id":"W2687519416","doi":"10.1038/nn.4592","title":"Germline Chd8 haploinsufficiency alters brain development in mouse","year":2017,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":280,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Institute of Dental and Craniofacial Research; National Human Genome Research Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; MIND Institute, University of California, Davis; University of California Berkeley; Fondation Brain Canada; Lawrence Berkeley National Laboratory; National Heart, Lung, and Blood Institute; Ontario Brain Institute; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ciência sem Fronteiras; Intellectual and Developmental Disabilities Research Center; University of California, Davis; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Energy","keywords":"Haploinsufficiency; Neuroscience; Biology; Autism; Chromatin remodeling; Neural development; Chromatin; Genetics; Phenotype; Gene; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002172966,0.0001260911,0.00009124491,0.00004623326,0.0002906986,0.0001068908,0.0008161934,0.0001604565,0.000001831913],"category_scores_gemma":[0.0004481765,0.0001188326,0.00003294043,0.00005646135,0.0001489611,0.000007933427,0.0002900147,0.0002312049,0.000003630145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001873424,"about_ca_system_score_gemma":0.0001271551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005746126,"about_ca_topic_score_gemma":0.00009575282,"domain_scores_codex":[0.9989271,0.00001615474,0.0001594564,0.0004490334,0.0001672763,0.0002809661],"domain_scores_gemma":[0.9992161,0.000005535934,0.00011197,0.0005624552,0.00003302903,0.00007094628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008307352,0.00006686705,0.005615133,0.000005929286,7.184036e-7,0.000009310525,0.00003616302,0.0002360398,0.9925122,0.000144893,0.0002466548,0.001117846],"study_design_scores_gemma":[0.001071632,0.0002676791,0.3663141,0.00002364317,0.000002781007,0.00004420612,0.00002550042,0.006673523,0.5354533,0.00008402077,0.08939686,0.0006427253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976948,0.00009207254,0.0003695698,0.0006353202,0.0003937479,0.0001080786,0.000007508623,0.000008018189,0.0006908722],"genre_scores_gemma":[0.995988,0.00004163951,0.0009962242,0.001732912,0.00005160045,0.000006608385,0.000009279118,0.00001244743,0.001161343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4570588,"threshold_uncertainty_score":0.4845852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007905612191009902,"score_gpt":0.2614706882895944,"score_spread":0.2535650760985845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}