{"id":"W2687519416","doi":"10.1038/nn.4592","title":"Germline Chd8 haploinsufficiency alters brain development in mouse","year":2017,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":280,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Institute of Dental and Craniofacial Research; National Human Genome Research Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; MIND Institute, University of California, Davis; University of California Berkeley; Fondation Brain Canada; Lawrence Berkeley National Laboratory; National Heart, Lung, and Blood Institute; Ontario Brain Institute; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ciência sem Fronteiras; Intellectual and Developmental Disabilities Research Center; University of California, Davis; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Energy","keywords":"Haploinsufficiency; Neuroscience; Biology; Autism; Chromatin remodeling; Neural development; Chromatin; Genetics; Phenotype; Gene; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636277,0.0005199879,0.0003135677,0.001512644,0.0003048155,0.0005859031,0.000616447,0.0009554829,0.005822493],"category_scores_gemma":[0.0002219046,0.0005478212,0.0002717372,0.0003141536,0.00077859,0.0003507899,0.000542292,0.001344091,0.0007501156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004550932,"about_ca_system_score_gemma":0.0002473022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117349,"about_ca_topic_score_gemma":0.002967285,"domain_scores_codex":[0.9996465,0.0000236644,0.00003190525,0.0001265951,0.0001028503,0.00006838092],"domain_scores_gemma":[0.9995459,0.00008034256,0.0001603255,0.00004589794,0.00002682499,0.0001406785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009492347,0.00002030881,0.0002685509,0.00001710503,0.000006051345,0.0001481285,0.00001929902,0.00006396369,0.9978139,0.0002938314,0.00007761841,0.001176305],"study_design_scores_gemma":[0.00004830441,0.0001252629,0.01084486,0.00001852035,0.00004810645,0.000747494,0.0001086696,0.001115538,0.9825236,0.0003638273,0.004041662,0.00001418091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892452,0.0009906407,0.004358309,0.0003321362,0.0001188876,0.00002140829,0.001364431,0.0004629325,0.003106069],"genre_scores_gemma":[0.9805288,0.0007281026,0.002736308,0.0002075063,0.00003038602,0.00004754581,0.000685177,0.0003891837,0.01464699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005822493,"threshold_uncertainty_score":0.01947814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007905612191009902,"score_gpt":0.2614706882895944,"score_spread":0.2535650760985845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}