{"id":"W26909110","doi":"10.1182/blood.v122.21.3932.3932","title":"Novel Inhibitors Of CRM1/XPO1 Nuclear Exporter Exhibit Striking Activity Against AML “primagrafts,” Including AML Leukemia Initiating Cells, While Sparing Normal Hematopoietic Cells","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Cancer research; Haematopoiesis; Myeloid leukemia; Leukemia; Nuclear export signal; Bone marrow; Apoptosis; Biology; Myeloid; Cell culture; Immunology; Stem cell; Cell nucleus; Cell biology; Biochemistry; Genetics; Cytoplasm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001155024,0.000364384,0.0002602705,0.0001927726,0.0001112814,0.0001782281,0.0001867046,0.0001330979,0.001275604],"category_scores_gemma":[0.0000675179,0.0001116823,0.0001726813,0.0001045645,0.0001620591,0.0001202026,0.0001089122,0.000456093,0.0002525014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001709249,"about_ca_system_score_gemma":0.0001715488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004214793,"about_ca_topic_score_gemma":0.001275931,"domain_scores_codex":[0.9999526,0.000007055119,0.000005600792,0.000009391125,0.00001216344,0.0000132114],"domain_scores_gemma":[0.9999514,0.00001010459,0.00001153104,0.000006642039,0.000005240179,0.00001512617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003553056,0.0001458831,0.0002267397,0.00007793317,0.00001683834,0.00005072408,0.00001610533,0.0002431718,0.9922149,0.0001579979,0.0001575088,0.006336892],"study_design_scores_gemma":[0.0001099977,0.001570966,0.002181157,0.000004866853,0.00002375785,0.000217795,0.00001014139,0.000815325,0.9919899,0.0000249705,0.003047193,0.000003952576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918108,0.002517388,0.001850914,0.00008635872,0.00002909263,0.00006221372,0.0002539064,0.0001610285,0.003228395],"genre_scores_gemma":[0.9929597,0.001920418,0.001809626,0.0000502978,0.00001141871,0.00004725285,0.0006633238,0.00001954496,0.002518466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001275604,"threshold_uncertainty_score":0.004267275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01250205205187322,"score_gpt":0.2036476133563583,"score_spread":0.191145561304485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}