{"id":"W2692981981","doi":"10.1038/ncomms15884","title":"Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Endosome; Intracellular; Extracellular; Cell biology; Hypoxia (environmental); Chemistry; Cytoplasm; Endocytosis; Receptor; Biology; Biochemistry; Biophysics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008899874,0.00009098562,0.0001480371,0.00007581455,0.0001048222,0.0001783124,0.00008722533,0.0002267109,0.001289519],"category_scores_gemma":[0.00008736402,0.00007418171,0.0001716931,0.00005205174,0.0001220337,0.0001710916,0.0002130654,0.0003524599,0.0002444238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002196085,"about_ca_system_score_gemma":0.00007629547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002799995,"about_ca_topic_score_gemma":0.0002741576,"domain_scores_codex":[0.9999092,0.00001554028,0.000007255263,0.00001343977,0.00002428342,0.00003027105],"domain_scores_gemma":[0.9999312,0.000009660874,0.0000226329,0.00000873485,0.000008665934,0.00001906179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001648718,0.00001106354,0.00025094,0.0000238779,0.000004210743,0.0001216784,0.000008077978,0.00004073331,0.9983287,0.0001515045,0.0001002578,0.0007941161],"study_design_scores_gemma":[0.00002497253,0.0002552222,0.02339752,0.000007200256,0.000008031333,0.001221734,0.00004471169,0.001199219,0.9700272,0.0002247987,0.003584889,0.000004618507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929867,0.002007529,0.002319346,0.0003894258,0.00006416488,0.00002169934,0.0002892729,0.00005883385,0.001863035],"genre_scores_gemma":[0.9970017,0.000600816,0.0006103928,0.00009161189,0.00001820231,0.00001124511,0.0001543478,0.000005598998,0.001506094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289519,"threshold_uncertainty_score":0.004313886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02382276937263766,"score_gpt":0.2955861365158571,"score_spread":0.2717633671432194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}