{"id":"W2693468451","doi":"10.1016/s0923-7534(20)33072-6","title":"Lux-Lung 8: A Randomized, Open-Label, Phase III Trial of Afatinib vs. Erlotinib in Patients with Advanced Squamous Cell Carcinoma of the Lung as Second-Line Therapy Following First-Line Platinum-Based Chemotherapy","year":2012,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Afatinib; Medicine; Erlotinib; Oncology; Internal medicine; Squamous-cell carcinoma of the lung; Lung; Basal cell; Platinum; Lung cancer; Gefitinib; Carcinoma; Open label; Randomized controlled trial; Epidermal growth factor receptor; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001679996,0.002216812,0.003530474,0.0005111833,0.000512656,0.001515304,0.001374996,0.002041136,0.008073355],"category_scores_gemma":[0.001661425,0.0008051674,0.002188419,0.0004537444,0.00157243,0.001974665,0.0005236339,0.005346706,0.001790605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001177099,"about_ca_system_score_gemma":0.001229162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001213757,"about_ca_topic_score_gemma":0.004222529,"domain_scores_codex":[0.9994107,0.0002695302,0.00003003672,0.0001119556,0.00003760711,0.0001401228],"domain_scores_gemma":[0.9992903,0.0001720072,0.0001414854,0.00005880039,0.00003744366,0.0002998972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9641471,0.008196553,0.0009031515,0.0004776158,0.000879091,0.00005181908,0.0000749697,0.0007082839,0.003077763,0.0002041079,0.001571252,0.01970829],"study_design_scores_gemma":[0.9560418,0.04148895,0.0009989387,0.00001424204,0.0002354076,0.00004057163,0.00002806718,0.0004161909,0.0002227222,0.0001415066,0.0003563927,0.00001519187],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915768,0.002132794,0.0003706546,0.0009156729,0.0004865788,0.00152328,0.0009469178,0.0001704789,0.001876893],"genre_scores_gemma":[0.9881313,0.001658884,0.00107225,0.001139176,0.0003915028,0.002198107,0.001600821,0.00004128613,0.00376657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008073355,"threshold_uncertainty_score":0.02700806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03861108824468808,"score_gpt":0.3984599953154056,"score_spread":0.3598489070707175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}