{"id":"W2696298149","doi":"10.1016/j.tem.2017.05.004","title":"AMPK as a Therapeutic Target for Treating Metabolic Diseases","year":2017,"lang":"en","type":"review","venue":"Trends in Endocrinology and Metabolism","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":628,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"AMPK; Insulin resistance; Fatty liver; AMP-activated protein kinase; Adipose tissue; Medicine; Type 2 diabetes; Endocrinology; Protein kinase A; Internal medicine; Biology; Insulin; Diabetes mellitus; Disease; Kinase; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000205128,0.0007868935,0.002619723,0.0004927103,0.0002577507,0.00006803078,0.000632677,0.0005582943,0.0001053906],"category_scores_gemma":[0.0001886808,0.0006449355,0.0007740689,0.000157206,0.0003475666,0.00001436542,0.0002287056,0.0003561029,0.00001176619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001238011,"about_ca_system_score_gemma":0.0002326738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004182113,"about_ca_topic_score_gemma":0.00004674964,"domain_scores_codex":[0.9967821,0.0003379335,0.0006814661,0.001100985,0.0001305985,0.0009669512],"domain_scores_gemma":[0.9981617,0.00008289645,0.0005173607,0.0009948179,0.00005981505,0.0001833867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000407493,0.00007838047,0.00002526221,0.0006722444,0.0005542965,0.00000890213,0.00002868602,4.713403e-7,0.0000092068,0.004084545,0.0003831892,0.994114],"study_design_scores_gemma":[0.001384311,0.00008256128,0.0001730746,0.0002524205,0.001992174,0.00005995648,0.00001438925,0.00000135797,0.0001241542,0.0009951566,0.9942912,0.00062924],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002147698,0.9963543,0.00002721905,0.00001689175,0.001052428,0.0005239366,0.0004803869,0.0000305204,0.001299507],"genre_scores_gemma":[0.0002259743,0.9923787,0.0003264527,0.0001828042,0.001414885,0.001320938,0.0009298132,0.0001118044,0.003108694],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.993908,"threshold_uncertainty_score":0.9996002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0593563929413533,"score_gpt":0.386431996618131,"score_spread":0.3270756036767777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}