{"id":"W2698366715","doi":"10.1039/c7ob01514c","title":"<sup>13</sup>C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions","year":2017,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Canadian Institutes of Health Research; King's College London; Wellcome Trust; AstraZeneca","keywords":"Halide; Chemistry; Ion; Nuclear magnetic resonance spectroscopy; Spectroscopy; Stereochemistry; Combinatorial chemistry; Inorganic chemistry; Organic chemistry; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003914631,0.0003572956,0.0001649339,0.0001514901,0.0003099263,0.0002641761,0.0006376538,0.0006314905,0.002782817],"category_scores_gemma":[0.0003437597,0.0001497978,0.0001461225,0.0001269897,0.0007993893,0.0004097518,0.0002583838,0.0009056018,0.00030337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00035049,"about_ca_system_score_gemma":0.0002355078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008992121,"about_ca_topic_score_gemma":0.001212864,"domain_scores_codex":[0.9998637,0.00003156416,0.000004141332,0.00002286552,0.00004419797,0.00003336639],"domain_scores_gemma":[0.9998696,0.00005559361,0.00003059292,0.00001110937,0.00001804564,0.00001510659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004462836,0.00004867787,0.0002468756,0.0001240795,0.00001263129,0.0001889261,0.00005942007,0.0005151586,0.9890167,0.003033682,0.0006255953,0.005682088],"study_design_scores_gemma":[0.0000335287,0.0002495381,0.0007469375,0.00001064669,0.00001081768,0.0001848754,0.00005296103,0.001469795,0.9933529,0.0005503946,0.003323373,0.00001430067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9318667,0.006812089,0.02685942,0.002300849,0.0004073276,0.000112631,0.0004892336,0.0003339218,0.03081775],"genre_scores_gemma":[0.9898416,0.001655845,0.005458513,0.0004618303,0.00003435335,0.00004637816,0.0001863842,0.00003049236,0.00228454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002782817,"threshold_uncertainty_score":0.009309471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006916576679807513,"score_gpt":0.2401586960593011,"score_spread":0.2332421193794936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}