{"id":"W2699766133","doi":"10.1182/blood.v128.22.2934.2934","title":"High Frequency of Somatic Mutations of KMT2D and CARD11 Genes in Cold Agglutinin Disease","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Blood groups and transfusion","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Biology; Exome; Sanger sequencing; Missense mutation; Exome sequencing; Lymphoplasmacytic Lymphoma; Somatic evolution in cancer; Bone marrow; Genetics; Mutation; Cancer research; Immunology; Gene; Lymphoma; Waldenstrom macroglobulinemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002716188,0.0003286316,0.0002913248,0.001133523,0.0003240448,0.0004154473,0.0002150724,0.0005394434,0.002955409],"category_scores_gemma":[0.0008451536,0.0001380735,0.0002133746,0.0006976384,0.0003384876,0.0001404522,0.0003025211,0.0002817393,0.0004025545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001729224,"about_ca_system_score_gemma":0.0000714864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004620336,"about_ca_topic_score_gemma":0.0005829008,"domain_scores_codex":[0.9995762,0.00005966168,0.00005144022,0.000170634,0.00009552658,0.00004645486],"domain_scores_gemma":[0.9996835,0.00009534042,0.00008580364,0.00003000205,0.00003386673,0.00007153161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001357313,0.0001396914,0.8906379,0.0001050832,0.0001197684,0.03294834,0.0004263177,0.0002174402,0.0573313,0.0002902674,0.001282696,0.01514392],"study_design_scores_gemma":[0.00008256558,0.0002945796,0.8946425,0.00004240589,0.0001262361,0.09197389,0.0002959814,0.0009048915,0.008873713,0.0002819232,0.002456731,0.00002458556],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980379,0.0003343472,0.0003886807,0.00002960264,0.00001039437,0.00002118308,0.0003581588,0.0000133822,0.0008063836],"genre_scores_gemma":[0.9995092,0.00003966248,0.0001495966,0.00002118381,0.000005849178,0.000003354454,0.000161471,0.00000306277,0.000106493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002955409,"threshold_uncertainty_score":0.009886801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008355205314155624,"score_gpt":0.220668010735335,"score_spread":0.2123128054211794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}