{"id":"W2701578380","doi":"10.1007/s11095-017-2197-0","title":"Design and Evaluation of RGD-Modified Gemini Surfactant-Based Lipoplexes for Targeted Gene Therapy in Melanoma Model","year":2017,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Pulmonary surfactant; Melanoma; Genetic enhancement; Pharmaceutical technology; Pharmacology; Chemistry; Cancer research; Medicine; Computational biology; Gene; Biology; Chromatography; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003368886,0.0002717683,0.0001871403,0.0001863402,0.0001343693,0.0002177827,0.0001786174,0.0003244578,0.000328516],"category_scores_gemma":[0.0001947585,0.0001267703,0.0002262647,0.0001440081,0.0001361716,0.0002604627,0.0001377842,0.000264773,0.0001286101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003525853,"about_ca_system_score_gemma":0.0002857889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004480065,"about_ca_topic_score_gemma":0.0006710568,"domain_scores_codex":[0.9999032,0.00001788799,0.00001284236,0.0000220838,0.0000276657,0.00001628112],"domain_scores_gemma":[0.9999175,0.00001009184,0.00002759916,0.000006008923,0.00002199533,0.00001672672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007245943,0.000025902,0.00006930969,0.00003807254,0.00000459008,0.00002213125,0.00001061647,0.0002245822,0.9981187,0.00009656205,0.00001378672,0.001303155],"study_design_scores_gemma":[0.00001739379,0.0002793084,0.0002659558,0.000002427143,0.00001240841,0.00003954864,0.000005069994,0.001040117,0.9975181,0.0000140374,0.0008030178,0.00000278094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867811,0.001677237,0.01059393,0.00007159723,0.00001825681,0.000156684,0.0001221938,0.00004733953,0.0005317117],"genre_scores_gemma":[0.9811136,0.001682187,0.01505724,0.00005141478,0.000006707276,0.0001301853,0.0002471435,0.00001911197,0.00169251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004480065,"threshold_uncertainty_score":0.002558231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4145853485191153,"score_gpt":0.5158499509962368,"score_spread":0.1012646024771214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}