{"id":"W2702369505","doi":"10.1038/s41598-017-04762-x","title":"Heart Failure and MEF2 Transcriptome Dynamics in Response to β-Blockers","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research; York University; Canadian Diabetes Association; Heart and Stroke Foundation of Canada","keywords":"Transcriptome; Mef2; Heart failure; Downregulation and upregulation; Biology; Gene expression; Enhancer; Cell biology; Apoptosis; Transcription factor; Muscle hypertrophy; Cancer research; Internal medicine; Gene; Medicine; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009538844,0.0001350103,0.0003019123,0.0002004704,0.0001256325,0.0002556393,0.00006157428,0.0001795745,0.000939404],"category_scores_gemma":[0.0001323453,0.00009497601,0.0002124419,0.0002078347,0.00009448577,0.0001325181,0.0001580061,0.0002458901,0.0002309319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009323684,"about_ca_system_score_gemma":0.0000832387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003857187,"about_ca_topic_score_gemma":0.0005393881,"domain_scores_codex":[0.9999224,0.000008393616,0.000003376218,0.00002498349,0.00001719691,0.00002366448],"domain_scores_gemma":[0.9999378,0.00001102805,0.00001932082,0.000004871696,0.00001043039,0.00001657838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005233589,0.00002036687,0.007365732,0.00005239185,0.00002792833,0.00004353912,0.00004802164,0.0001449626,0.9892347,0.00003661288,0.0001092942,0.002393115],"study_design_scores_gemma":[0.00002551287,0.0003827384,0.8854515,0.00002522807,0.00008442141,0.0003022484,0.0002770675,0.002122998,0.1088228,0.0001662988,0.00232062,0.00001862479],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962054,0.000997057,0.0006604369,0.00004520644,0.00001482493,0.00000617041,0.001512873,0.00002117179,0.0005367515],"genre_scores_gemma":[0.9941729,0.0006716841,0.0005490105,0.0001008015,0.00001815652,0.00004259554,0.002777903,0.00001556029,0.001651402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000939404,"threshold_uncertainty_score":0.003142595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00947482863569186,"score_gpt":0.2647380779601981,"score_spread":0.2552632493245062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}