{"id":"W2702886506","doi":"10.1200/jco.2016.34.15_suppl.507","title":"PALOMA-2: Primary results from a phase III trial of palbociclib (P) with letrozole (L) compared with letrozole alone in postmenopausal women with ER+/HER2– advanced breast cancer (ABC).","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Palbociclib; Letrozole; Clinical endpoint; Internal medicine; Hazard ratio; Breast cancer; Cancer; Progression-free survival; Adverse effect; Oncology; Gynecology; Randomized controlled trial; Metastatic breast cancer; Confidence interval; Tamoxifen; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002947318,0.002786407,0.002498732,0.0006012465,0.0004996124,0.001307894,0.001623978,0.001753022,0.01240392],"category_scores_gemma":[0.002396998,0.0008255018,0.002162189,0.0004553862,0.001176036,0.001282956,0.0006705477,0.004720429,0.002202464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001069115,"about_ca_system_score_gemma":0.001894626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001189312,"about_ca_topic_score_gemma":0.003213449,"domain_scores_codex":[0.9993193,0.0003759601,0.00002988705,0.00009229517,0.00005800308,0.0001245066],"domain_scores_gemma":[0.9987069,0.0003623793,0.0002665375,0.00009616841,0.00007484856,0.00049311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9586694,0.01449507,0.0008010321,0.0006121861,0.0008638413,0.00007503835,0.00005902146,0.0004124904,0.004100903,0.00008862876,0.002727336,0.01709508],"study_design_scores_gemma":[0.904254,0.09119442,0.002184791,0.00003093253,0.0005115044,0.00007437033,0.00002136867,0.0002735289,0.0004987855,0.0001296129,0.0008141801,0.00001255115],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641553,0.006350478,0.001065438,0.001590744,0.0004516485,0.009746837,0.008898318,0.0003790317,0.007362268],"genre_scores_gemma":[0.9690964,0.002951476,0.001830904,0.001948428,0.0006169383,0.008823218,0.008381584,0.00009344734,0.006257636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01240392,"threshold_uncertainty_score":0.04149532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04252982893718386,"score_gpt":0.4039353674576152,"score_spread":0.3614055385204313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}