{"id":"W2702886506","doi":"10.1200/jco.2016.34.15_suppl.507","title":"PALOMA-2: Primary results from a phase III trial of palbociclib (P) with letrozole (L) compared with letrozole alone in postmenopausal women with ER+/HER2– advanced breast cancer (ABC).","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Palbociclib; Letrozole; Clinical endpoint; Internal medicine; Hazard ratio; Breast cancer; Cancer; Progression-free survival; Adverse effect; Oncology; Gynecology; Randomized controlled trial; Metastatic breast cancer; Confidence interval; Tamoxifen; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0017106,0.0004495024,0.003782515,0.0002602124,0.00005036652,0.000009453734,0.0003585256,0.0003297014,0.0002259633],"category_scores_gemma":[0.0003422746,0.0002303586,0.0001649946,0.0004471624,0.001026989,0.0004676962,0.00006609793,0.001079452,0.000004118377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001052514,"about_ca_system_score_gemma":0.003917209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003107267,"about_ca_topic_score_gemma":0.0008748047,"domain_scores_codex":[0.9937519,0.0005156895,0.003446762,0.0005861861,0.0009906038,0.0007088649],"domain_scores_gemma":[0.9911332,0.002418898,0.004347284,0.0005613596,0.0008681803,0.0006710397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.764905,0.005309836,0.01085168,0.00002824293,0.001162854,0.001122568,0.000470172,0.0001057313,0.008204206,0.000005974044,0.0001039013,0.2077298],"study_design_scores_gemma":[0.7184447,0.09296251,0.1756796,0.001542901,0.0004322712,0.0007056424,0.0006225737,0.000009048992,0.0005567351,0.00009431411,0.008605695,0.0003440203],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987689,0.0004586286,0.0006532563,0.009098107,0.0003994381,0.0008593499,0.0003846194,0.00002807851,0.000429561],"genre_scores_gemma":[0.9878516,0.0004029858,0.008559393,0.001515122,0.001320721,0.00007192846,0.00001963478,0.00007880771,0.0001798372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2073857,"threshold_uncertainty_score":0.939375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04252982893718386,"score_gpt":0.4039353674576152,"score_spread":0.3614055385204313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}