{"id":"W2709936120","doi":"10.1111/cbdd.13054","title":"RNA‐dependent RNA polymerase: Addressing Zika outbreak by a phylogeny‐based drug target study","year":2017,"lang":"en","type":"letter","venue":"Chemical Biology & Drug Design","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"Zika virus; RNA polymerase; Virology; Biology; Microcephaly; Outbreak; RNA; RNA-dependent RNA polymerase; Phylogenetics; Computational biology; Flavivirus; Genetics; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003602112,0.000257609,0.0003875509,0.000245486,0.0003813346,0.0005692765,0.0004291927,0.002828383,0.0009876507],"category_scores_gemma":[0.001182925,0.0001296319,0.0003046168,0.0001581917,0.0004915189,0.0007133156,0.0002988079,0.002399131,0.0007185778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009472557,"about_ca_system_score_gemma":0.0004355484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005488359,"about_ca_topic_score_gemma":0.001058129,"domain_scores_codex":[0.9998299,0.00005770952,0.00001293899,0.0000212545,0.00005489917,0.00002321341],"domain_scores_gemma":[0.9997604,0.0001026081,0.00002935953,0.00001516326,0.00004559391,0.0000468753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000947225,0.000928239,0.01833165,0.001272082,0.0001285345,0.04201743,0.0004935334,0.006381129,0.05343728,0.03021465,0.3755985,0.4702497],"study_design_scores_gemma":[0.0007515803,0.00189553,0.009966622,0.0005547512,0.0001950086,0.05815011,0.001045632,0.06048565,0.02229878,0.0440261,0.8005276,0.000102612],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.07738221,0.08470647,0.0158692,0.789668,0.008298084,0.0002780991,0.0001523099,0.0003572726,0.02328848],"genre_scores_gemma":[0.6327155,0.1002169,0.03223014,0.2010983,0.0158303,0.0003977557,0.0003389701,0.00008270656,0.01708945],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002828383,"threshold_uncertainty_score":0.006872833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02882624179763223,"score_gpt":0.2983835775766762,"score_spread":0.269557335779044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}