{"id":"W2709936120","doi":"10.1111/cbdd.13054","title":"RNA‐dependent RNA polymerase: Addressing Zika outbreak by a phylogeny‐based drug target study","year":2017,"lang":"en","type":"letter","venue":"Chemical Biology & Drug Design","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"Zika virus; RNA polymerase; Virology; Biology; Microcephaly; Outbreak; RNA; RNA-dependent RNA polymerase; Phylogenetics; Computational biology; Flavivirus; Genetics; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0006237827,0.001203943,0.002241065,0.0002086485,0.0003473182,0.0001460247,0.001300309,0.001460613,0.0009102563],"category_scores_gemma":[0.0004113281,0.0009812812,0.000758971,0.0001141961,0.0005933185,0.00006885508,0.0002626221,0.002897107,0.0001950696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002502026,"about_ca_system_score_gemma":0.0006622575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002414683,"about_ca_topic_score_gemma":0.000001489695,"domain_scores_codex":[0.994194,0.0007286792,0.0009776447,0.001994766,0.0006444267,0.001460509],"domain_scores_gemma":[0.9956445,0.0006675724,0.0007843792,0.002138223,0.0002222268,0.0005431776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006797556,0.0007788508,0.0005130444,0.0001556165,0.0007270685,0.001457302,0.00007923149,5.419077e-7,0.2532473,9.485758e-7,0.7387689,0.003591356],"study_design_scores_gemma":[0.02070518,0.0009282035,0.0001699909,0.0009322553,0.00563757,0.0001151641,0.0002349327,0.0004920922,0.5390476,0.0003013443,0.4281135,0.003322207],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1478126,0.06556701,0.004061495,0.7562261,0.004172915,0.0126937,0.00436115,0.001246602,0.003858425],"genre_scores_gemma":[0.6892367,0.00004684695,0.000423742,0.2924486,0.006496787,0.000760251,0.004282741,0.0002451804,0.006059214],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.5414241,"threshold_uncertainty_score":0.9998357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02882624179763223,"score_gpt":0.2983835775766762,"score_spread":0.269557335779044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}