{"id":"W2712490288","doi":"10.1128/jvi.00518-17","title":"Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity","year":2017,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; AIDS Vancouver","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Victor Daitz Foundation; National Research Foundation; Michael Smith Health Research BC; Howard Hughes Medical Institute; Canada Research Chairs; Wellcome Trust","keywords":"Biology; Virology; Viral replication; Protease; Transmission (telecommunications); Lentivirus; Virus; Recombinant DNA; Genetics; Viral disease; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002885011,0.0001300998,0.0002927196,0.000172227,0.0001848595,0.000380899,0.0002126818,0.0001598128,0.003184325],"category_scores_gemma":[0.0008551463,0.0001186625,0.00009540992,0.00009300738,0.0001377963,0.0002182774,0.0002130252,0.0002742297,0.000320853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002022387,"about_ca_system_score_gemma":0.0001889558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006036768,"about_ca_topic_score_gemma":0.0004903946,"domain_scores_codex":[0.9998497,0.0000335524,0.000008649276,0.00003889527,0.00003081679,0.00003831807],"domain_scores_gemma":[0.9995041,0.0002044019,0.0001343002,0.00004160084,0.00004813157,0.00006747494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001046738,0.0002857116,0.3308605,0.0001261904,0.00004652315,0.0008730407,0.0005906131,0.0001567922,0.650752,0.0006275103,0.0003806454,0.01425366],"study_design_scores_gemma":[0.00006033019,0.001320438,0.8953599,0.0000508384,0.00006299594,0.005905994,0.001066265,0.002868086,0.09143497,0.000377077,0.001473528,0.00001958801],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995034,0.0001318323,0.0001412301,0.00001038674,0.000001284647,0.000003329336,0.00002943658,0.000004564337,0.0001745538],"genre_scores_gemma":[0.999449,0.00006632883,0.0002498242,0.0000151664,0.000002900616,0.000005907918,0.00007415206,0.000005212586,0.0001316325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003184325,"threshold_uncertainty_score":0.0106526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02403093464532833,"score_gpt":0.2846299673113843,"score_spread":0.2605990326660559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}