{"id":"W2720368458","doi":"10.1371/journal.ppat.1006464","title":"Helicobacter pylori gene silencing in vivo demonstrates urease is essential for chronic infection","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Helicobacter pylori-related gastroenterology studies","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Australian Research Council; Medical Research Council; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; University of Western Australia; Australian Government; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; U.S. Department of Commerce; Government of Western Australia; National Science Foundation","keywords":"Biology; Microbiology; Helicobacter pylori; Urease; Pathogen; Virulence factor; Gene; Chronic infection; CagA; Virulence; Mutant; Immune system; Gene silencing; Gene expression; Genetics; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002004751,0.0002495476,0.000256994,0.000157312,0.0001076195,0.0003596749,0.0002290208,0.0004167487,0.001770828],"category_scores_gemma":[0.0001950585,0.0001791578,0.000200231,0.00009551168,0.0003256773,0.000219509,0.0003219429,0.0007220618,0.0005078461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002532027,"about_ca_system_score_gemma":0.0002548424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005461958,"about_ca_topic_score_gemma":0.0007199953,"domain_scores_codex":[0.999813,0.00002183814,0.00001881224,0.00004305143,0.00005409911,0.00004920526],"domain_scores_gemma":[0.9997982,0.0000392521,0.00004726875,0.00003110853,0.0000172212,0.0000669209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005173602,0.00001461971,0.00008413143,0.00001457644,0.00000190938,0.00002673838,0.000008867921,0.00002148745,0.9990343,0.0001325918,0.00004390385,0.0005651796],"study_design_scores_gemma":[0.00004738972,0.0007481418,0.008399332,0.00001676863,0.00002273387,0.0004302718,0.00005683611,0.002270189,0.9812078,0.0003493664,0.00643845,0.00001267866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843374,0.002046717,0.008761706,0.0004983236,0.0001408146,0.00003774932,0.0007295439,0.0003109811,0.003136829],"genre_scores_gemma":[0.9925639,0.0008058895,0.002061764,0.0001352802,0.00002168578,0.00004407105,0.0005656078,0.0001014682,0.003700466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001770828,"threshold_uncertainty_score":0.005923986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0257329715740608,"score_gpt":0.2815489485601297,"score_spread":0.2558159769860689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}