{"id":"W2720368458","doi":"10.1371/journal.ppat.1006464","title":"Helicobacter pylori gene silencing in vivo demonstrates urease is essential for chronic infection","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Helicobacter pylori-related gastroenterology studies","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Australian Research Council; Medical Research Council; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; University of Western Australia; Australian Government; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; U.S. Department of Commerce; Government of Western Australia; National Science Foundation","keywords":"Biology; Microbiology; Helicobacter pylori; Urease; Pathogen; Virulence factor; Gene; Chronic infection; CagA; Virulence; Mutant; Immune system; Gene silencing; Gene expression; Genetics; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001958946,0.0003020774,0.0005008788,0.0001940232,0.0004003556,0.000058109,0.0001433458,0.0002369362,0.0001065187],"category_scores_gemma":[0.0003502884,0.0002854934,0.0001824762,0.00008717724,0.0001770616,0.0002229488,0.0001151931,0.0003138215,0.00005795358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002555656,"about_ca_system_score_gemma":0.0001340477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001396375,"about_ca_topic_score_gemma":0.0004880955,"domain_scores_codex":[0.9981619,0.00004525787,0.0004280077,0.0005303907,0.0001922877,0.0006421684],"domain_scores_gemma":[0.9986771,0.00005510428,0.0002302405,0.0006476024,0.0002129055,0.0001770554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001743067,0.0002253368,0.4987757,0.0001094245,0.0003269736,0.0000801299,0.0003837282,0.000004431129,0.4987693,0.000004588958,0.0002772205,0.0008689168],"study_design_scores_gemma":[0.004693137,0.0009631726,0.5839208,0.0003547202,0.0007518425,0.0001057778,0.00005132336,0.001360244,0.4068511,0.00004893421,0.0005868939,0.0003120145],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960767,0.0002032525,0.0002967434,0.001650383,0.0005052669,0.000789899,0.000156065,0.00009525927,0.0002264189],"genre_scores_gemma":[0.9973927,0.0003273123,0.0005302489,0.00040894,0.0008684783,0.000216052,0.00003286783,0.00005251362,0.0001708857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09191816,"threshold_uncertainty_score":0.9999597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0257329715740608,"score_gpt":0.2815489485601297,"score_spread":0.2558159769860689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}