{"id":"W2721469237","doi":"10.1002/wnan.1465","title":"Promise and peril in nanomedicine: the challenges and needs for integrated systems biology approaches to define health risk","year":2017,"lang":"en","type":"review","venue":"Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology","topic":"Nanoparticles: synthesis and applications","field":"Materials Science","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Nanomedicine; Risk analysis (engineering); Engineering ethics; Management science; Engineering; Nanotechnology; Medicine; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003709356,0.0007175205,0.003984334,0.0007093472,0.0006055943,0.00006830343,0.000768432,0.0006315788,0.000009049083],"category_scores_gemma":[0.0004123956,0.0003843356,0.0001555522,0.0004030862,0.00125608,0.0000833555,0.001087965,0.0005596502,0.00001586097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000106061,"about_ca_system_score_gemma":0.0001630309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006185166,"about_ca_topic_score_gemma":0.00009351021,"domain_scores_codex":[0.9958305,0.0005904351,0.001691568,0.001115972,0.00009544814,0.0006760482],"domain_scores_gemma":[0.9967738,0.0005304418,0.001275759,0.00114916,0.00003880223,0.0002320448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002505927,0.00006517626,0.000007051229,0.008802186,0.0000348519,0.000001824604,0.0008267099,3.502609e-8,0.0001844717,0.003854951,0.0004943695,0.9857033],"study_design_scores_gemma":[0.0005032998,0.001204664,0.0000108328,0.02463452,0.000306568,0.0002734161,0.001038251,0.00002996556,0.00001833091,0.0005938557,0.9710039,0.0003823367],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001278788,0.9796796,0.0001296624,0.0117752,0.0003022892,0.006507406,0.0002076633,0.0000683935,0.0000509319],"genre_scores_gemma":[0.001994027,0.9925851,0.0005789107,0.00007661094,0.0001858302,0.004376597,0.00005139022,0.00005520852,0.00009630233],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.985321,"threshold_uncertainty_score":0.9998609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2499384678922615,"score_gpt":0.3823656517723223,"score_spread":0.1324271838800609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}