{"id":"W2724281717","doi":"10.1038/nrd.2017.115","title":"Remyelination therapies: a new direction and challenge in multiple sclerosis","year":2017,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":277,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Remyelination; Multiple sclerosis; Medicine; Neuroscience; Myelin; Clinical trial; Regeneration (biology); Central nervous system; Immunology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002360084,0.0008687605,0.002643988,0.003013386,0.0004288981,0.002218156,0.001406314,0.002297676,0.00403924],"category_scores_gemma":[0.003140188,0.0003251341,0.0008358211,0.002916961,0.001221098,0.00294645,0.001199283,0.003754069,0.001613673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001026453,"about_ca_system_score_gemma":0.003336059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001729902,"about_ca_topic_score_gemma":0.004869714,"domain_scores_codex":[0.9994312,0.0001527217,0.0001123972,0.00006881518,0.000191808,0.00004310215],"domain_scores_gemma":[0.9973346,0.001782044,0.000220637,0.00005293202,0.0004985897,0.0001111122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001094915,0.00005638002,0.0001609272,0.03555512,0.0001625325,0.0001732731,0.00008769712,0.0002128531,0.0009287554,0.00655891,0.03954937,0.9164447],"study_design_scores_gemma":[0.0000451313,0.00009832081,0.0004685428,0.0151559,0.0002994093,0.0006412732,0.0001372257,0.00008117229,0.0002429056,0.004961539,0.9778399,0.00002874123],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002369081,0.9988989,0.00006192687,0.0006413824,0.0001880095,0.000001814174,0.000008437227,0.000003374255,0.0001724711],"genre_scores_gemma":[0.000259549,0.9986125,0.0001598768,0.0005580417,0.0002459241,0.000003108813,0.00001066005,0.000001088338,0.0001492405],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00403924,"threshold_uncertainty_score":0.01351255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.237417829957524,"score_gpt":0.4205014691636489,"score_spread":0.1830836392061249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}