{"id":"W2724321370","doi":"10.1098/rsob.170081","title":"Cell signalling pathway regulation by RanBPM: molecular insights and disease implications","year":2017,"lang":"en","type":"review","venue":"Open Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Institute of Cancer Research; Canadian Institutes of Health Research","keywords":"Biology; Ubiquitin ligase; Ubiquitin; Cell biology; Ubiquitin-Protein Ligases; Saccharomyces cerevisiae; Signal transduction; Cytoplasm; Nuclear protein; Transcription factor; Yeast; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002121364,0.0003799802,0.0007341615,0.00005301532,0.0002934899,0.0001502773,0.0008935713,0.0005454343,0.00003431339],"category_scores_gemma":[0.00009819211,0.000320471,0.0001929565,0.00004742211,0.000155688,0.000007656423,0.0006925951,0.0001744325,0.00003291308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001624236,"about_ca_system_score_gemma":0.0003931357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001738687,"about_ca_topic_score_gemma":0.000003611048,"domain_scores_codex":[0.9981543,0.0003095733,0.0003821141,0.0008321451,0.00004701886,0.0002748663],"domain_scores_gemma":[0.9982981,0.00002848224,0.0004529085,0.0008895155,0.00006400645,0.0002669971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004183719,0.0001067619,0.0000188685,0.001922909,0.0001682245,0.000007092968,0.00001603587,5.289173e-7,0.09176516,0.002947827,0.004773458,0.8982313],"study_design_scores_gemma":[0.0002488088,0.0001044309,0.000003865809,0.0003868223,0.0001390183,0.000008299185,0.000001320448,0.000001554669,0.003928663,0.00146059,0.9933097,0.0004069236],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001631322,0.9920238,0.0008755438,0.00007311526,0.00008353814,0.001396713,0.0004799572,0.0000103347,0.004893837],"genre_scores_gemma":[0.003204793,0.9876678,0.0003223272,0.0001490014,0.000145835,0.0004832154,0.006425831,0.00005711383,0.001544114],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9885362,"threshold_uncertainty_score":0.9999247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05937133228919372,"score_gpt":0.3475326021313312,"score_spread":0.2881612698421375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}