{"id":"W2724482787","doi":"10.1016/j.neuropharm.2017.06.031","title":"Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain","year":2017,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Fundamental Research Funds for the Central Universities; National Natural Science Foundation of China","keywords":"Chronic pain; Synaptogenesis; Sensitization; Long-term potentiation; CREB; SNi; Neuroscience; Medicine; Neuropathic pain; Excitatory postsynaptic potential; Hyperalgesia; Psychology; Inhibitory postsynaptic potential; Nociception; Biology; Internal medicine; Receptor; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002884411,0.001069134,0.001260181,0.0005082117,0.0002965401,0.0005859823,0.0005824182,0.0006866863,0.00631065],"category_scores_gemma":[0.0007073764,0.0003305108,0.0006214568,0.0003035696,0.001335839,0.0009366937,0.0003504849,0.003578838,0.001016325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00060532,"about_ca_system_score_gemma":0.001258942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008757234,"about_ca_topic_score_gemma":0.002238996,"domain_scores_codex":[0.9996713,0.00002802475,0.00002346728,0.0000400825,0.00004469165,0.000192436],"domain_scores_gemma":[0.9994687,0.00008832602,0.0001044635,0.00006537962,0.00005049891,0.0002225481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01309789,0.002145033,0.0002839036,0.000364124,0.00005596177,0.0001851689,0.00009761795,0.0002853771,0.970175,0.000794578,0.0005187445,0.01199663],"study_design_scores_gemma":[0.001465082,0.01598078,0.009815469,0.00007108,0.0001433943,0.0004792941,0.0001914161,0.002652721,0.9655798,0.0004733279,0.003098725,0.00004883613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906069,0.001903179,0.002817247,0.0004352964,0.0003803019,0.0001604164,0.0004828451,0.000375494,0.002838251],"genre_scores_gemma":[0.9919513,0.001373554,0.001405572,0.0001270783,0.0001030596,0.000178922,0.0003987363,0.00004495256,0.004416762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00631065,"threshold_uncertainty_score":0.02111119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02082330747261628,"score_gpt":0.2858253809750167,"score_spread":0.2650020735024004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}