{"id":"W2724571272","doi":"10.1038/nature22992","title":"Recurrent and functional regulatory mutations in breast cancer","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":319,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute","keywords":"Promoter; Gene; Biology; Genetics; FOXA1; Breast cancer; Coding region; Computational biology; Cancer research; Transcription factor; Cancer; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000290952,0.0002624552,0.000295899,0.001209101,0.0002765655,0.0004376386,0.0004373815,0.0007458694,0.001763633],"category_scores_gemma":[0.0008525383,0.0001899221,0.0002026773,0.0007254547,0.0004377751,0.0002370903,0.0002714376,0.0003741031,0.0003647277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004027823,"about_ca_system_score_gemma":0.0002341139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008757155,"about_ca_topic_score_gemma":0.001376938,"domain_scores_codex":[0.9997161,0.00003227416,0.00003249232,0.00006314324,0.0001122633,0.00004363813],"domain_scores_gemma":[0.999572,0.0001126145,0.0001603028,0.00005325683,0.00003425558,0.00006766803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00135024,0.0001646307,0.1042742,0.0001760102,0.0001826294,0.01444017,0.0003766066,0.002815653,0.8027716,0.005636386,0.001245126,0.06656685],"study_design_scores_gemma":[0.0001287656,0.0007862868,0.5430507,0.0000826276,0.0007594717,0.1166836,0.0004242081,0.009114209,0.2941758,0.008357067,0.02634906,0.00008808052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919042,0.003310491,0.001268519,0.0002457385,0.0000477409,0.000008926055,0.0003474151,0.0001126888,0.002754222],"genre_scores_gemma":[0.9981443,0.0005646842,0.0004149101,0.00005347584,0.00003360152,0.000004049031,0.0001215665,0.0000223625,0.000641087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763633,"threshold_uncertainty_score":0.005899966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008908599047618454,"score_gpt":0.2637427554002021,"score_spread":0.2548341563525837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}