{"id":"W2724749320","doi":"10.1016/j.ab.2017.07.006","title":"Osmotic regulation of the mitochondrial permeability transition pore investigated by light scattering, fluorescence and electron microscopy techniques","year":2017,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"National Institutes of Health; American Heart Association","keywords":"Mitochondrial permeability transition pore; Biophysics; Permeability (electromagnetism); Fluorescence; Mitochondrion; Chemistry; Osmotic pressure; Calcium; Mitochondrial matrix; Inner mitochondrial membrane; Membrane; Membrane curvature; Membrane potential; Mitochondrial membrane transport protein; Cytosol; Biochemistry; Biology; Enzyme; Apoptosis; Lipid bilayer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003102953,0.0002240786,0.0002279935,0.0002502922,0.0003941359,0.000557359,0.0003472606,0.0003160733,0.0004736154],"category_scores_gemma":[0.0004273001,0.0001670494,0.000245895,0.0002258548,0.0007454288,0.001035639,0.0003803877,0.0007930264,0.0001313775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000576634,"about_ca_system_score_gemma":0.0002419056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008559916,"about_ca_topic_score_gemma":0.0009387531,"domain_scores_codex":[0.9998035,0.00003530561,0.00001313435,0.00002512605,0.00008325531,0.00003969296],"domain_scores_gemma":[0.999568,0.000145954,0.0001179863,0.00004669251,0.0000779644,0.00004336721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000103664,0.00001026828,0.0001884598,0.00001027314,0.000003059135,0.00002243347,0.0000364306,0.00006285165,0.9987237,0.0003986928,0.00001279915,0.0004273963],"study_design_scores_gemma":[0.00001209929,0.00005459343,0.005003625,0.000003008466,0.000007615103,0.0001512101,0.00005923456,0.002810289,0.9908285,0.0004363351,0.0006231369,0.00001040645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860731,0.0009628816,0.01098664,0.0002182247,0.00002604886,0.00001668832,0.0001456827,0.0000813568,0.001489267],"genre_scores_gemma":[0.9964946,0.0004158202,0.002305649,0.00004325147,0.00001103515,0.00001402808,0.0001037614,0.00003491398,0.0005768345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008559916,"threshold_uncertainty_score":0.004183769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006688099538903553,"score_gpt":0.2609387173992755,"score_spread":0.254250617860372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}