{"id":"W2724782240","doi":"10.1139/cjpp-2016-0333","title":"Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice","year":2017,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CREB; PI3K/AKT/mTOR pathway; Protein kinase B; Tropomyosin receptor kinase B; Neuroprotection; Brain-derived neurotrophic factor; Chemistry; Morris water navigation task; TUNEL assay; Neurotrophic factors; Terminal deoxynucleotidyl transferase; Neurotoxicity; Pharmacology; Apoptosis; Endocrinology; Biology; Transcription factor; Biochemistry; Hippocampus; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003282402,0.000194707,0.0005117957,0.0004100596,0.0003177946,0.00001640764,0.0004337961,0.0001968709,0.0000309879],"category_scores_gemma":[0.0003617589,0.000181778,0.00007603414,0.000131635,0.0007863292,0.0002719136,0.00006298694,0.0006659459,9.266299e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004276535,"about_ca_system_score_gemma":0.0005229171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0019796,"about_ca_topic_score_gemma":0.0008626472,"domain_scores_codex":[0.9980764,0.0006252162,0.0004264087,0.0003259884,0.0001426304,0.0004033685],"domain_scores_gemma":[0.9981914,0.0005961987,0.0005894779,0.0001361227,0.0001543543,0.0003324312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005418278,0.0000374704,0.001612492,0.0002492132,0.0000292587,0.0001072708,0.00107233,0.00004700451,0.9944194,0.0001178171,0.000009419231,0.001756493],"study_design_scores_gemma":[0.001449439,0.001075071,0.04971221,0.00008218423,0.00002909592,0.00008343144,0.00004201456,0.0004566468,0.9458032,0.001112736,0.00001821032,0.0001357552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986246,0.0001288053,0.00001090929,0.0004902604,0.0001731268,0.0005288598,0.00001432804,0.000003671538,0.00002540559],"genre_scores_gemma":[0.9993687,0.00007983518,0.00001731703,0.0003927697,0.0000995382,0.00001378078,9.16931e-7,0.00001718411,0.000009911205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0486162,"threshold_uncertainty_score":0.7412692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03137321781235344,"score_gpt":0.2739696965102213,"score_spread":0.2425964786978679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}