{"id":"W2724792141","doi":"10.1038/celldisc.2017.22","title":"Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities","year":2017,"lang":"en","type":"article","venue":"Cell Discovery","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; McMaster University","funders":"Associazione Italiana per la Ricerca sul Cancro; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Metformin; Tensin; Cancer research; microRNA; Pharmacology; PI3K/AKT/mTOR pathway; Cancer; Everolimus; Medicine; Ectopic expression; Chemistry; Signal transduction; PTEN; Internal medicine; Cell biology; Endocrinology; Biology; Diabetes mellitus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427511,0.0002549498,0.000297802,0.0002195754,0.0001376353,0.000264646,0.0001367682,0.0002307682,0.0009662763],"category_scores_gemma":[0.0001132219,0.0001630264,0.0002353686,0.0001199421,0.0001763475,0.000145011,0.0001446192,0.0005074714,0.0003193725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002524805,"about_ca_system_score_gemma":0.0003110574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003642204,"about_ca_topic_score_gemma":0.000677457,"domain_scores_codex":[0.9998775,0.00001475984,0.00001529412,0.00001969273,0.00004205377,0.00003071214],"domain_scores_gemma":[0.9999458,0.00000951304,0.00001795276,0.000006395206,0.000005424881,0.00001483839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001258293,0.00002723259,0.00007154,0.00001882736,0.000003430921,0.00003604998,0.000005508865,0.00005066815,0.9986238,0.00007393548,0.00004148049,0.0009215883],"study_design_scores_gemma":[0.00002170366,0.0001985699,0.001903954,0.000002313404,0.00001087288,0.0001457889,0.00001036974,0.001072545,0.9937511,0.00003083862,0.002848344,0.000003632003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945427,0.001326093,0.00181686,0.0001179794,0.00006778724,0.00004210752,0.000344972,0.00009698163,0.00164449],"genre_scores_gemma":[0.9942588,0.0007482821,0.001753558,0.00007003205,0.00001370388,0.00005600107,0.000663153,0.00002411522,0.002412319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009662763,"threshold_uncertainty_score":0.003232539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258245227828128,"score_gpt":0.2471922883050424,"score_spread":0.2346098360267611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}